gene

VPS13C

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VPS13C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

71Connections
0Hypotheses
0Analyses
26Outgoing
45Incoming

Summary

Page for VPS13C Gene - Vacuolar Protein Sorting 13 Homolog C

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🧬 Gene Info
Gene SymbolVPS13C
Full NameVacuolar Protein Sorting 13 Homolog C
AliasesPage for VPS13C Gene
Chromosome15q22.31
FunctionVPS13C is a member of the VPS13 family of lipid-transfer proteins.
Molecular Weight395 kDa
Amino Acids100 aa
Exons77
PathwayscGAS-STING pathway
UniProt IDQ9UPQ0
NCBI Gene ID86728
Ensembl IDENSG00000129048
GeneCardsVPS13C
Human Protein AtlasVPS13C
Associated DiseasesAls, Alzheimer, Ms, Parkinson, Parkinson's disease
InteractionsATP13A2, DNAJC6, FBXO7, PINK1, PLA2G6, PRKN
KG Connections71 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: VPS13C — AlphaFold Q9UPQ0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (19)

Knowledge base pages for this entity

Canonical Page

VPS13C Gene - Vacuolar Protein Sorting 13 Homolog C

gene · 649 words

Synucleinopathy Mechanism

mechanism · 4870 words

Mitochondria-Lysosome Contact Site Dysfunction in Parkinson's Disease

mechanism · 3314 words

VPS13C Protein

protein · 2807 words

FBXO7 Protein (PARK15)

protein · 2779 words

VPS13 Lipid Transport and Organelle Contact Site Modulation Therapy

idea · 1517 words

Pathway Diagram

graph TD
    VPS13C["<b>VPS13C</b>"]
    Parkinson_s_disease{"Parkinson's disease"}
    VPS13C -->|"associated with"| Parkinson_s_disease
    lipid_transfer_protein["lipid transfer protein"]
    VPS13C -->|"encodes"| lipid_transfer_protein
    cGAS_STING_pathway(["cGAS-STING pathway"])
    VPS13C -->|"regulates"| cGAS_STING_pathway
    mitochondrial_DNA_accumulation(["mitochondrial DNA accumulation"])
    VPS13C -->|"activates"| mitochondrial_DNA_accumulation
    Ms{"Ms"}
    VPS13C -->|"associated with"| Ms
    MITOPHAGY["MITOPHAGY"]
    VPS13C -->|"associated with"| MITOPHAGY
    BNIP3L["BNIP3L"]
    VPS13C -->|"associated with"| BNIP3L
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    VPS13C -->|"associated with"| IMMUNE_INFILTRATION
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    VPS13C -->|"associated with"| OXIDATIVE_STRESS
    MAP1LC3B["MAP1LC3B"]
    VPS13C -->|"associated with"| MAP1LC3B
    Oxidative_Stress(["Oxidative Stress"])
    VPS13C -->|"associated with"| Oxidative_Stress
    Mitophagy(["Mitophagy"])
    VPS13C -->|"associated with"| Mitophagy
    style VPS13C fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (26)

TargetRelationTypeStr
lipid transfer proteinencodesprotein0.70
mitochondrial DNA accumulationactivatesprocess0.70
Parkinson's diseaseassociated_withdisease0.70
cGAS-STING pathwayregulatespathway0.70
Msassociated_withdisease0.65

Incoming (45)

SourceRelationTypeStr
ATP13A2interacts_withgene0.70
DNAJC6interacts_withgene0.70
FBXO7interacts_withgene0.70
PINK1interacts_withgene0.70
PRKNinteracts_withgene0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found