Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about VPS13C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | VPS13C |
| Full Name | Vacuolar Protein Sorting 13 Homolog C |
| Aliases | Page for VPS13C Gene |
| Chromosome | 15q22.31 |
| Function | VPS13C is a member of the VPS13 family of lipid-transfer proteins. |
| Molecular Weight | 395 kDa |
| Amino Acids | 100 aa |
| Exons | 77 |
| Pathways | cGAS-STING pathway |
| UniProt ID | Q9UPQ0 |
| NCBI Gene ID | 86728 |
| Ensembl ID | ENSG00000129048 |
| GeneCards | VPS13C |
| Human Protein Atlas | VPS13C |
| Associated Diseases | Als, Alzheimer, Ms, Parkinson, Parkinson's disease |
| Interactions | ATP13A2, DNAJC6, FBXO7, PINK1, PLA2G6, PRKN |
| KG Connections | 71 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
VPS13C["<b>VPS13C</b>"]
Parkinson_s_disease{"Parkinson's disease"}
VPS13C -->|"associated with"| Parkinson_s_disease
lipid_transfer_protein["lipid transfer protein"]
VPS13C -->|"encodes"| lipid_transfer_protein
cGAS_STING_pathway(["cGAS-STING pathway"])
VPS13C -->|"regulates"| cGAS_STING_pathway
mitochondrial_DNA_accumulation(["mitochondrial DNA accumulation"])
VPS13C -->|"activates"| mitochondrial_DNA_accumulation
Ms{"Ms"}
VPS13C -->|"associated with"| Ms
MITOPHAGY["MITOPHAGY"]
VPS13C -->|"associated with"| MITOPHAGY
BNIP3L["BNIP3L"]
VPS13C -->|"associated with"| BNIP3L
IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
VPS13C -->|"associated with"| IMMUNE_INFILTRATION
OXIDATIVE_STRESS["OXIDATIVE STRESS"]
VPS13C -->|"associated with"| OXIDATIVE_STRESS
MAP1LC3B["MAP1LC3B"]
VPS13C -->|"associated with"| MAP1LC3B
Oxidative_Stress(["Oxidative Stress"])
VPS13C -->|"associated with"| Oxidative_Stress
Mitophagy(["Mitophagy"])
VPS13C -->|"associated with"| Mitophagy
style VPS13C fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| lipid transfer protein | encodes | protein | 0.70 |
| mitochondrial DNA accumulation | activates | process | 0.70 |
| Parkinson's disease | associated_with | disease | 0.70 |
| cGAS-STING pathway | regulates | pathway | 0.70 |
| Ms | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| BNIP3L | associated_with | gene | 0.60 |
| MAP1LC3B | associated_with | gene | 0.60 |
| DNAJC6 | associated_with | gene | 0.60 |
| ATP13A2 | associated_with | gene | 0.60 |
| PLA2G6 | associated_with | gene | 0.60 |
| PRKN | associated_with | gene | 0.60 |
| ATP1A3 | associated_with | gene | 0.60 |
| SNCA | associated_with | gene | 0.60 |
| LRRK2 | associated_with | gene | 0.60 |
| VPS35 | associated_with | gene | 0.60 |
| MITOPHAGY | associated_with | gene | 0.60 |
| IMMUNE INFILTRATION | associated_with | gene | 0.60 |
| OXIDATIVE STRESS | associated_with | gene | 0.60 |
| Oxidative Stress | associated_with | pathway | 0.60 |
| Mitophagy | associated_with | pathway | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| stem cells | expressed_in | cell_type | 0.60 |
| Parkinson's disease | translocates_to | disease | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ATP13A2 | interacts_with | gene | 0.70 |
| DNAJC6 | interacts_with | gene | 0.70 |
| FBXO7 | interacts_with | gene | 0.70 |
| PINK1 | interacts_with | gene | 0.70 |
| PRKN | interacts_with | gene | 0.70 |
| SYNJ1 | interacts_with | gene | 0.70 |
| ATP13A2 | associated_with | gene | 0.70 |
| PLA2G6 | associated_with | gene | 0.70 |
| PRKN | associated_with | gene | 0.70 |
| GCH1 | associated_with | gene | 0.60 |
| VPS35 | associated_with | gene | 0.60 |
| GBA1 | associated_with | gene | 0.60 |
| TARDBP | associated_with | gene | 0.60 |
| PARK7 | associated_with | gene | 0.60 |
| DNAJC13 | associated_with | gene | 0.60 |
| FBXO7 | associated_with | gene | 0.60 |
| PINK1 | associated_with | gene | 0.60 |
| PLA2G6 | interacts_with | gene | 0.60 |
| DJ1 | interacts_with | gene | 0.60 |
| GBA1 | interacts_with | gene | 0.60 |
| LRRK2 | interacts_with | gene | 0.60 |
| PARK7 | interacts_with | gene | 0.60 |
| SNCA | interacts_with | gene | 0.60 |
| ATP13A2 | expressed_in | gene | 0.60 |
| DJ1 | expressed_in | gene | 0.60 |
| DNAJC6 | expressed_in | gene | 0.60 |
| FBXO7 | expressed_in | gene | 0.60 |
| GBA1 | expressed_in | gene | 0.60 |
| LRRK2 | expressed_in | gene | 0.60 |
| PINK1 | expressed_in | gene | 0.60 |
| PRKN | expressed_in | gene | 0.60 |
| SNCA | expressed_in | gene | 0.60 |
| SYNJ1 | expressed_in | gene | 0.60 |
| BAG3 | targets | gene | 0.60 |
| GBA1 | targets | gene | 0.60 |
| LRRK2 | targets | gene | 0.60 |
| RIT2 | targets | gene | 0.60 |
| SCARB2 | targets | gene | 0.60 |
| SNCA | targets | gene | 0.60 |
| TMEM175 | targets | gene | 0.60 |
| ATP1A3 | associated_with | gene | 0.60 |
| DNAJC6 | associated_with | gene | 0.60 |
| LRRK2 | associated_with | gene | 0.60 |
| SNCA | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||