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mechanism 2,522 words KG: ent-gene-7b80a607
Contents

mTOR Signaling in Autophagy and Lysosomal Function

🔬 Protein Info
Gene Symbolent-gene-7b80a607
mTORThe catalytic serine/threonine kinase subunit
RaptorRegulatory protein that recruits substrates
mLST8Stabilizes the complex
PRAS40 and DeptorNegative regulators
Autophagy genesATG proteins, LC3, p62/SQSTM1
Lysosomal genesCathepsins, V-ATPase, LAMP proteins
Biogenesis genesTFEB itself, MITF family
KG Connections7 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

Wikipedia

Related Hypotheses (78)

Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65Glial Glycocalyx Remodeling Therapy
Score: 0.65Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61Netrin-1 Gradient Restoration
Score: 0.59TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.57Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54Lysosomal Membrane Repair Enhancement
Score: 0.54Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48Optogenetic Control of Mitochondrial Transfer Networks
Score: 0.48Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43Gap Junction Hemichannel Modulation for Controlled Mitochond
Score: 0.36Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69APOE-Dependent Autophagy Restoration
Score: 0.89Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
← Prevpg 3/4Next →

Related Analyses (30)

Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedEpigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (15)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40Leukocyte gene expression analysis in COVID-19 patients
exploratory · proposed · Score: 0.90RBG treatment in ApoE-/- atherosclerosis mouse model
validation · proposed · Score: 0.90Trehalose-induced lysosomal membrane permeabilization and TF
exploratory · proposed · Score: 0.90

See Also (15)

Synaptic Therapy Alzheimer's Research Trial (START): A
clinical · Pages share 4 hypothesesAlzheimer's Disease Circadian Rhythm and Sleep-Wake Cyc
company · Pages share 4 hypothesesVILIP-1 and YKL-40 - Alzheimer's Disease Biomarkers
biomarker · Pages share 4 hypothesesMicroglia in Alzheimer's Disease Neurodegeneration
cell · Pages share 4 hypothesesAlzheimer's Disease Adenosine Receptor and Purinergic S
company · Pages share 4 hypotheses

Knowledge Graph (7 edges)

31112550 fails to mediate ent-gene-7b80a607
h-810ec0eb targets ent-gene-7b80a607
ent-gene-7b80a607 targeted_by h-810ec0eb
h-82100428d0 targets ent-gene-7b80a607
ent-gene-7b80a607 targeted_by h-82100428d0
h-894b633a targets ent-gene-7b80a607
ent-gene-7b80a607 targeted_by h-894b633a

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