Contents

PDE4B — Phosphodiesterase 4B

🧬 Gene Info

Gene Symbol	PDE4B
Full Name	Phosphodiesterase 4B
Chromosome	1p31.3
Protein Type	Enzyme
Function	is a member of the phosphodiesterase 4 family that specifically hydrolyzes cyclic AMP (cAMP), terminating cAMP-mediated signaling.
Primary Expression	brain - PDE4B2: 664 amino acids, the most abundant isoform in immune cells - PDE4B3: 726 amino acids, enriched in testis and brain - PDE4B4
Subcellular Localization	and protein-protein interactions. The upstream control region contains multiple transcription factor binding sites, incl
Amino Acids	721 aa
Exons	16
Pathways	Mitophagy, Oxidative Stress, neuronal apoptosis
UniProt ID	[Q07343](https://www.uniprot.org/uniprot/Q07343)
Ensembl ID	ENSG00000104288
OMIM	610172
GeneCards	PDE4B
Human Protein Atlas	PDE4B
Associated Diseases	Als, Alzheimer, dementia
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS, APP, APP/PS1
KG Connections	97 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Knowledge Graph