Contents

DISC1 — Disrupted in Schizophrenia 1

🧬 Gene Info

Gene Symbol	DISC1
Full Name	Disrupted in Schizophrenia 1
Chromosome	1q42.2
Protein Type	Scaffold Protein
Function	Centrosomal function: DISC1 localizes to the centrosome where it interacts with NDEL1, LIS1, and dynein to regulate neuronal migration during cortical development
Primary Expression	Hippocampus, Cerebral cortex, Cerebellum, Dentate gyrus
Exons	13
Pathways	Akt, Apoptosis, Complement, Exocytosis, Mitochondrial Function
UniProt ID	Q9NRI5
NCBI Gene ID	27185
Ensembl ID	ENSG00000162946
OMIM	605210
GeneCards	DISC1
Human Protein Atlas	DISC1
Associated Diseases	AD, ALI, Als, Alzheimer, Amyotrophic Lateral Sclerosis
Interactions	ABCD3, Actin, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1
KG Connections	771 knowledge graph edges
Databases	GeneCards HPA STRING

Knowledge Graph