protein 1,513 words KG: A2MPROTEIN 2026-03-27
kind:proteinsection:proteinsstate:published
Contents

A2M Protein

🔬 Protein Info
Gene SymbolA2M
AliasesA2MPROTEIN
Chromosome12p13.31 (human)
Protein Familyα2-macroglobulin family
FunctionThe protein possesses a unique "trap" mechanism
Subcellular Localization</strong></td><td>Secreted (plasma)</td></tr>
Molecular Weight~720 kDa (tetramer)
Amino Acids1450 amino acids
UniProt IDP01023
NCBI Gene ID2
GeneCardsA2M
Human Protein AtlasA2M
Associated DiseasesAD, AMI, Als, Alzheimer, Alzheimer's disease, Depression
InteractionsDHCR24, HMGCR, MAPT, PARP1, PEN2, PSEN1
KG Connections107 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
LRP1-Dependent Tau Uptake Disruption
Score: 0.44
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Senescent Cell Clearance in Neurodegeneration
mechanism · Pages share 4 hypotheses
RNA-Targeted Therapies in Neurodegeneration
mechanism · Pages share 4 hypotheses
PPAR Signaling Pathway in Neurodegeneration
mechanism · Pages share 4 hypotheses
Neurovascular Unit Dysfunction in Neurodegeneration
mechanism · Pages share 4 hypotheses