| Gene Symbol | AKT1 |
| Aliases | AKT1PROTEIN |
| Protein Type | Kinase |
| Function | is a serine/threonine protein kinase that serves as a central hub in the PI3K/AKT/mTOR signaling pathway, one of the most critical survival and growth signaling cascades in neurons. |
| Amino Acids | 480 aa |
| Pathways | Akt, Apoptosis, Autophagy, Immune Response, Mapk |
| Ensembl ID | ENSG00000142208 |
| GeneCards | AKT1 |
| Human Protein Atlas | AKT1 |
| Target | Function |
| [mTORC1](/entities/mtor) | Protein synthesis |
| [GSK-3β](/entities/gsk3-beta) | Tau phosphorylation |
| [FOXO](/entities/foxo-transcription-factors) | Gene transcription |
| [BAD](/entities/bcl-2-family) | Apoptosis |
| CREB | Gene transcription |
| Associated Diseases | ALS, Aging, Alzheimer, Alzheimer's Disease, Ataxia |
| Known Drugs/Compounds | COUMESTROL, Coumestrol, Atbc, DMP, Andrographis paniculata, quercetin |
| Interactions | SQSTM1, RPS6KB1, GRB2, RHEB, STING1, EIF2A |
| KG Connections | 1615 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |