entity

DEP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DEP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

30Hypotheses

0Analyses

6Outgoing

0Incoming

8Experiments

0Debates

No AI portrait yet

Wiki Pages (4)

Knowledge base pages for this entity

Outgoing (6)

Target	Relation	Type	Str
Breast Cancer	contributes_to	disease	0.90
MAPK1	binds	protein	0.90
ESR1	binds	protein	0.90
AKT1	binds	protein	0.85
SRC	binds	protein	0.85
Breast Cancer	risk_factor_for	disease	0.85

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
APOE-Dependent Autophagy Restoration	0.895	neurodegeneration	Survival Analysis of AD Patient Cohorts:
SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senesc	0.893	neurodegeneration	Gene expression changes in aging mouse b
Elevated CSF/Serum Albumin Quotient Predicts Neurodegenerati	0.850	-	What blood-brain barrier permeability ch
ATM Kinase Hyperactivation Triggers DNA Damage Response Over	0.837	als	-
Activity-Dependent CD55/CD46 Trafficking and Synaptic Surfac	0.833	synaptic-biology	What determines the selectivity of compl

CREB-Dependent Differential Complement Regulator Positioning	0.833	synaptic-biology	What determines the selectivity of compl
SIRT1 Activation Couples Mitochondrial Biogenesis to Ferropt	0.824	neurodegeneration	Can ferroptosis inhibitors prevent BBB d
Kinetic Modeling Predicts Threshold-Dependent Efficacy—Early	0.815	protein-folding	Can chaperone enhancement approaches ove
TREM2-Dependent Switch Hypothesis: TREM2 Agonism Redirects S	0.813	synaptic-biology	Does SPP1-mediated synaptic engulfment r
LRP1-Dependent Tau Uptake Disruption	0.808	neurodegeneration	Tau propagation mechanisms and therapeut
Sleep-Dependent Glymphatic Clearance Expands the Therapeutic	0.780	neurodegeneration	What is the therapeutic window between t
Gamma entrainment induces activity-dependent BDNF release to	0.773	alzheimers	Gamma entrainment therapy to restore hip
Lysosomal Cathepsin-Dependent Tau Clearance	0.767	neurodegeneration	Does the cancer-cystatin-C-TREM2 pathway
STMN2 Cryptic Exon Inclusion is the Earliest Loss-of-Functio	0.760	als	Causal Sequence of TDP-43 Nuclear Cleara
Night-phase orexin receptor antagonism rescues AD by restori	0.758	neurodegeneration	Orexin-A manipulation in AD cognition an
Senescence-Activated NAD+ Depletion Rescue	0.755	neurodegeneration	Senolytic therapy for age-related neurod
Near-infrared light therapy stimulates COX4-dependent mitoch	0.742	neurodegeneration	Mitochondrial transfer between astrocyte
MEF2C-Dependent Synaptic Gene Regulation	0.740	neurodegeneration	What molecular mechanisms mediate HDAC9'
Mutant-dependent amplification is context-dependent and stro	0.740	neurodegeneration	Do pathogenic LRRK2 mutations amplify vo
G2019S Acts as Lysosomal Volume-Sensing Amplifier via Enhanc	0.730	neurodegeneration	Do pathogenic LRRK2 mutations amplify vo
Calcium-Dependent S100B Release from Astrocyte End-Feet as a	0.725	-	What blood-brain barrier permeability ch
Context-Dependent Cx43 Modulation Based on Disease Stage	0.724	cell-biology	What is the relative contribution of con
Regional TREM2-Dependent Lipid Metabolism Determines Cortica	0.721	neuroinflammation	How do regional, age, and sex-dependent
TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegen	0.716	neurodegeneration	TREM2 in Alzheimer's Disease: Mechanisms
Microglial Disease-Associated States: TREM2-Independent Path	0.710	neurodegeneration	Cell type vulnerability debate in Alzhei
SCFA-Producing Bacterial Depletion → Loss of Neuroprotective	0.700	neurodegeneration	What are the mechanisms by which gut mic
SARM1-Mediated NAD+ Depletion as Terminal Executor of MCT1-D	0.698	neurodegeneration	What is the molecular mechanism by which
Microglial P2Y12-Dependent Territorial Segregation of Synapt	0.697	synaptic-biology	What determines the selectivity of compl
TFEB-Independent Autophagy Bypass	0.697	neurodegeneration	Does TFEB dysfunction cause neurodegener
LAMP1 Overexpression to Enhance Lysosomal Capacity Independe	0.000	proteomics	Quantitative proteomics of the aging syn

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (8)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Mobile App-Based Intervention for BPSD in Community-Dwelling Dementia	clinical	dementia with behavioral and p	0.950	human patients	proposed	N/A
Meta-analysis of LRP1 C766T polymorphism and Alzheimer's disease susce	exploratory	Alzheimer's disease	0.950	human patients	proposed	N/A
iPSC-NPC effects on astrocytes in vitro ICH model	exploratory	intracerebral hemorrhage	0.900	in vitro ICH cell culture mode	completed	N/A
Irisin effects on osteogenic differentiation in mesenchymal stem cells	exploratory	bone fracture	0.900	mouse bone mesenchymal stem ce	proposed	N/A
AMPK knockdown validation experiment	exploratory	intracerebral hemorrhage	0.880	astrocyte cell culture	proposed	N/A
P2RY12-MTOR pathway interaction in VSMCs	exploratory	atherosclerosis	0.850	cultured VSMCs	proposed	N/A
iPSC-NPC transplantation in ICH animal model	validation	intracerebral hemorrhage	0.850	animal ICH model	proposed	N/A
HDAC4 inhibition and NHE6 expression mechanism study	exploratory	Alzheimer's disease	0.850		proposed	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Replating Induces mTOR-Dependent Rescue of Protein Synthesis in Charcot-Marie-To [PMID:41876253]	Koenig J, McGuire A, Homedan Y, Alberhas	eNeuro	2026
S-equol promotes ferroptosis in triple negative breast cancer by coordinating NC [PMID:41925800]	Ni F, Huang Z, Cui Y, Huang P, Xue Z, Hu	Molecular and cellular biochem	2026
Metabolic dysregulation reshapes the immune landscape: The gut microbiota-mTOR a [PMID:41445190]	Li J, Li J, Chen K	Mol Ther	2026
Senecavirus a VP2 protein orchestrates PRDX1 degradation through dual autophagy [PMID:41479169]	Li Z, Yang X, Mao J, Zeng P, Qi Y et al.	Autophagy	2026
Inhibition of mTOR Enhances the Efficacy of Proteasome-Dependent Targeted Protei [PMID:41529091]	Liu Y, Sun Y, Song TY, Ni SY, Pu YS et a	Cancer Res	2026
Microglial metabolic reprogramming in Alzheimer's disease: Pathways, mechanisms, [PMID:41651180]	Yang FG, Yang H, Han SW, Wang JT, Gao W	Ageing Res Rev	2026
mTOR signaling pathway in primary Sjögren's syndrome: Pathogenesis and potential [PMID:41789635]	Huo R, Yang Y, Wei C, Yang Y, Meng D et	Int J Mol Med	2026
Microcystin-LR-induced phosphorylation imbalance and organelle stress: An integr [PMID:41846138]	Teng Z, Shahzad A, Xu Z, Xia J, Zhang J	J Hazard Mater	2026
Copper deficiency impairs oligodendrocyte maturation and social behavior via mit [PMID:41920999]	Usui N, Doi M, Berto S, Matsuoka K, Ishi	Sci Adv	2026
Crosstalk between inflammation and autophagy in CeD organoids. [PMID:41933042]	Bellomo C, Furone F, Auricchio R, D'Anie	Sci Rep	2026
Targeting the AKT/mTOR axis: pectolinarigenin induces autophagy and apoptosis in [PMID:41924135]	Fang Y, Bai J, Bo S, Cui X, Song H, Guo	Frontiers in pharmacology	2026
Targeting the GSK-3β/mTOR axis: a novel pharmacological strategy for preeclampsi [PMID:41922823]	Alshaikh ABA, Al-Kuraishy HM, Abdelaziz	Naunyn-Schmiedeberg's archives	2026
Platelet proteomic signatures of amyloid β-positive mild cognitive impairment an [PMID:41904574]	Cho YE, Kim A, Lee HM, Oh JW, Son SJ, Ro	Molecular brain	2026
Targeting of the PI3K/AKT/mTOR signaling pathway in the neurovascular interface [PMID:41865874]	Alameen AAM, Al-Kuraishy HM, Al-Gareeb A	Microvascular research	2026
Neuroinflammation, Autophagy, and Neurodegeneration: Mechanisms and Therapeutic [PMID:41918200]	["Khanal P", "Balmik A"]	CNS & neurological disorders d	2026
Aromatic amino acid metabolism shapes autophagy-mediated adaptation to iron depr [PMID:41925978]	Zhao K, Ludwig-Radtke L, Wang Y, Rusch T	Biometals : an international j	2026
iPSC-NPC transplantation alleviates brain injury after intracerebral hemorrhage [PMID:41921697]	Zhong Z, Wang S, Xu C, Liu Q, Chen X, Li	Journal of stroke and cerebrov	2026
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Modulating mTOR-dependent astrocyte substate transitions to alleviate neurodegen [PMID:39779911]	Zhang L, Xu Z, Jia Z, Cai S, Wu Q, Liu X	Nature aging	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DEP in their description or question text

CREB-Dependent Differential Complement Regulator Positioning for Activity-Based

Score: 0.833 · synaptic-biology · 2026-04-28

This hypothesis proposes that the CREB-BDNF-TrkB activity-dependent signaling cascade directly controls the spatial posi

SIRT1 Activation Couples Mitochondrial Biogenesis to Ferroptosis Suppression via

Score: 0.824 · neurodegeneration · 2026-04-17

## Mechanistic Overview SIRT1 Activation Couples Mitochondrial Biogenesis to Ferroptosis Suppression via PGC1alpha-Depen

Kinetic Modeling Predicts Threshold-Dependent Efficacy—Early Intervention Requir

Score: 0.815 · protein-folding · 2026-04-22

**Molecular Mechanism and Rationale** The therapeutic hypothesis centers on the kinetic constraints governing chaperone

TREM2-Dependent Switch Hypothesis: TREM2 Agonism Redirects SPP1 Signaling from D

Score: 0.813 · synaptic-biology · 2026-04-21

## Mechanistic Overview TREM2-Dependent Switch Hypothesis: TREM2 Agonism Redirects SPP1 Signaling from Destructive to Re

LRP1-Dependent Tau Uptake Disruption

Score: 0.808 · neurodegeneration · 2026-04-16

## Mechanistic Overview LRP1-Dependent Tau Uptake Disruption starts from the claim that modulating LRP1 within the disea

Sleep-Dependent Glymphatic Clearance Expands the Therapeutic Window by Reducing

Score: 0.780 · neurodegeneration · 2026-04-22

## Mechanistic Overview Sleep-Dependent Glymphatic Clearance Expands the Therapeutic Window by Reducing Extracellular Ta

Gamma entrainment induces activity-dependent BDNF release to rescue NMJ and dend

Score: 0.773 · alzheimers · 2026-04-28

High-frequency gamma oscillations stimulate activity-dependent release of brain-derived neurotrophic factor (BDNF) from

Lysosomal Cathepsin-Dependent Tau Clearance

Score: 0.767 · neurodegeneration · 2026-04-17

## Mechanistic Overview Lysosomal Cathepsin-Dependent Tau Clearance starts from the claim that modulating not yet specif

STMN2 Cryptic Exon Inclusion is the Earliest Loss-of-Function Marker of TDP-43 N

Score: 0.760 · als · 2026-04-27

Loss of nuclear TDP-43 in ALS motor neurons first manifests as aberrant inclusion of the STMN2 cryptic exon 2a, producin

Night-phase orexin receptor antagonism rescues AD by restoring sleep-dependent c

Score: 0.758 · neurodegeneration · 2026-04-26

Timed OX1R/OX2R antagonism during the rest phase may consolidate sleep, improve glymphatic/interstitial clearance, and r

Senescence-Activated NAD+ Depletion Rescue

Score: 0.755 · neurodegeneration · 2026-04-02

## Mechanistic Overview Senescence-Activated NAD+ Depletion Rescue starts from the claim that modulating CD38/NAMPT with

Near-infrared light therapy stimulates COX4-dependent mitochondrial motility enh

Score: 0.742 · neurodegeneration · 2026-04-02

## Mechanistic Overview Near-infrared light therapy stimulates COX4-dependent mitochondrial motility enhancement starts

MEF2C-Dependent Synaptic Gene Regulation

Score: 0.740 · neurodegeneration · 2026-04-15

## **Molecular Mechanism and Rationale** The molecular basis for MEF2C-dependent synaptic gene regulation centers on a

Mutant-dependent amplification is context-dependent and strongest in microglia a

Score: 0.740 · neurodegeneration · 2026-04-24

A credible refinement is that any true amplification is not universal across cell types, but emerges most strongly in pr

G2019S Acts as Lysosomal Volume-Sensing Amplifier via Enhanced RAB29-Dependent R

Score: 0.730 · neurodegeneration · 2026-04-26

G2019S specifically hyperactivates LRRK2 when recruited to swelling lysosomes via RAB29, creating pathogenic positive fe

DEP