entity

DEP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DEP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

22Hypotheses

15Analyses

6Outgoing

0Incoming

Wiki Pages (20)

Knowledge base pages for this entity

Outgoing (6)

Target	Relation	Type	Str
MAPK1	binds	protein	0.90
ESR1	binds	protein	0.90
Breast Cancer	contributes_to	disease	0.90
AKT1	binds	protein	0.85
SRC	binds	protein	0.85
Breast Cancer	risk_factor_for	disease	0.85

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (22)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2-Dependent Microglial Senescence Transition	0.692	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegen	0.639	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Dependent Microglial Phagocytosis Acts as a Strain Sel	0.636	neurodegeneration	What are the specific molecular determin
APOE-Dependent Autophagy Restoration	0.615	neurodegeneration	Mechanistic role of APOE in neurodegener
SARM1-Mediated NAD+ Depletion as Terminal Executor of MCT1-D	0.614	neurodegeneration	What is the molecular mechanism by which

Senescence-Activated NAD+ Depletion Rescue	0.604	neurodegeneration	Senolytic therapy for age-related neurod
SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senesc	0.600	neurodegeneration	Gene expression changes in aging mouse b
Context-Dependent Cx43 Modulation Based on Disease Stage	0.579	cell biology	What is the relative contribution of con
MEF2C-Dependent Synaptic Gene Regulation	0.578	neurodegeneration	What molecular mechanisms mediate HDAC9'
TREM2 Signaling Bifurcation with Independent TYROBP-Independ	0.567	neuroinflammation	Why is TYROBP deficiency neuroprotective
SYK-Independent TREM2 Pathways Remain Functional in TYROBP D	0.555	neuroinflammation	Why is TYROBP deficiency neuroprotective
Near-infrared light therapy stimulates COX4-dependent mitoch	0.514	neurodegeneration	Mitochondrial transfer between astrocyte
TFEB-Independent Autophagy Bypass	0.510	neurodegeneration	Does TFEB dysfunction cause neurodegener
Context-Dependent CRISPR Activation in Specific Neuronal Sub	0.509	neurodegeneration	CRISPR-based therapeutic approaches for
Tau-Independent Microtubule Stabilization via MAP6 Enhanceme	0.480	neurodegeneration	Selective vulnerability of entorhinal co
Age-Dependent Complement C4b Upregulation Drives Synaptic Vu	0.470	neurodegeneration	Gene expression changes in aging mouse b
Microglial TREM2-Independent Pathway Activation	0.458	neurodegeneration	Which cell types show the most significa
TREM2-Dependent Microglial Surveillance Controls AQP4-Mediat	0.452	neuroscience	Circuit-level neural dynamics in neurode
CaMKII-Dependent Synaptic Circuit Amplification	0.444	neuroscience	Circuit-level neural dynamics in neurode
LRP1-Dependent Tau Uptake Disruption	0.437	Alzheimer's Disease	Tau propagation mechanisms and therapeut
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor	0.418	neurodegeneration	Mitochondrial transfer between neurons a
RAB27A-dependent extracellular vesicle engineering for mitoc	0.414	neurodegeneration	Mitochondrial transfer between astrocyte

Mentioning Analyses (15)

Scientific analyses that reference this entity

What molecular mechanisms explain how apoE promotes cerebral amyloid angiopathy

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.544

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.455

Why does autophagy inhibition improve neuronal survival when autophagy is typica

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.557

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.578

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

neurodegeneration | 2026-04-14 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Channeling Nicotinamide Phosphoribosyltransferase (NAMPT) to Address Life and De [PMID:38580317]	Velma GR, Krider IS, Alves ETM, Courey J	J Med Chem	2024	1
Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214]	Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia	J Inflamm Res	2022	1
TREM2, microglia, and Alzheimer's disease. [PMID:33516818]	Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang	Mech Ageing Dev	2021	1
NAD(+) metabolism, stemness, the immune response, and cancer. [PMID:33384409]	Navas LE, Carnero A	Signal Transduct Target Ther	2021	1
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797]	Zhou Y, Song WM, Andhey PS, Swain A, Lev	Nat Med	2020	1
NAD metabolism fuels human and mouse intestinal inflammation. [PMID:28877980]	Gerner RR, Klepsch V, Macheiner S, Arnha	Gut	2018	1
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. [PMID:28802038]	Ulland TK, Song WM, Huang SC, Ulrich JD,	Cell	2017	1
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663]	Krasemann S, Madore C, Cialic R, Baufeld	Immunity	2017	1
NAD+ and sirtuins in aging and disease. [PMID:24786309]	Imai S, Guarente L	Trends Cell Biol	2014	1
Replating Induces mTOR-Dependent Rescue of Protein Synthesis in Charcot-Marie-To [PMID:41876253]	Koenig J, McGuire A, Homedan Y, Alberhas	eNeuro	2026	0
S-equol promotes ferroptosis in triple negative breast cancer by coordinating NC [PMID:41925800]	Ni F, Huang Z, Cui Y, Huang P, Xue Z, Hu	Molecular and cellular biochem	2026	0
Metabolic dysregulation reshapes the immune landscape: The gut microbiota-mTOR a [PMID:41445190]	Li J, Li J, Chen K	Mol Ther	2026	0
Senecavirus a VP2 protein orchestrates PRDX1 degradation through dual autophagy [PMID:41479169]	Li Z, Yang X, Mao J, Zeng P, Qi Y et al.	Autophagy	2026	0
Sishen Wan suppresses colon cancer through dual inhibition of PI3K/AKT/mTOR and [PMID:41490553]	Wang C, Wang R, Xu Q, Jian Q, Li R et al	J Ethnopharmacol	2026	0
Huaiqihuang granule attenuate renal injury in IgA vasculitis nephritis by activa [PMID:41490554]	Ye XL, Zeng LS, Liu Q, Xu WC, Liu H et a	J Ethnopharmacol	2026	0
Inhibition of mTOR Enhances the Efficacy of Proteasome-Dependent Targeted Protei [PMID:41529091]	Liu Y, Sun Y, Song TY, Ni SY, Pu YS et a	Cancer Res	2026	0
Hepatoprotective effects of tetrahydropalmatine against NAFLD through autophagy [PMID:41544727]	Guo X, Yin X, Liu Z, Wang J	J Ethnopharmacol	2026	0
Microglial metabolic reprogramming in Alzheimer's disease: Pathways, mechanisms, [PMID:41651180]	Yang FG, Yang H, Han SW, Wang JT, Gao W	Ageing Res Rev	2026	0
Atractylon induces autophagy-dependent apoptosis in hepatocellular carcinoma cel [PMID:41713198]	Xu J, Yang H, Wei H, Li H, Wang S	Biochem Biophys Res Commun	2026	0
mTOR signaling pathway in primary Sjögren's syndrome: Pathogenesis and potential [PMID:41789635]	Huo R, Yang Y, Wei C, Yang Y, Meng D et	Int J Mol Med	2026	0

DEP

Understanding Entity Pages

Wiki Pages (20)

Synaptic Loss in Alzheimer's Disease Pathway

DVL3 — Dishevelled Segment Polarity Protein 3

RGS10 Gene

Oligodendrocyte-Myelin Dysfunction Hypothesis in Parkinson's Disease

RRAGA — Ras-Related GTP Binding A

Outgoing (6)

Incoming (0)

Targeting Hypotheses (22)

Mentioning Analyses (15)

What molecular mechanisms explain how apoE promotes cerebral amyloid angiopathy

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

Why does autophagy inhibition improve neuronal survival when autophagy is typica

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

How does HDAC1/2 deletion specifically enhance microglial amyloid phagocytosis c

Can TREM2 receptor switching from agonism to antagonism be achieved safely witho

Why do structurally diverse sugars (trehalose, melibiose, lactulose) produce ide

What determines the spatial organization of autophagy receptors at stress granul

What determines the specificity of calcium-dependent PPP3/calcineurin activation

What is the optimal therapeutic window timing for autophagy enhancement versus s

How does TRIM21-mediated K63 ubiquitination of G3BP1 mechanistically inhibit liq

How do pathological stress granules in neurodegeneration escape TRIM21/autophagy

Human connectome alterations and network-level dysfunction in Alzheimer disease

Related Papers (20)

DEP

Understanding Entity Pages

Wiki Pages (20)

Synaptic Loss in Alzheimer's Disease Pathway

DVL3 — Dishevelled Segment Polarity Protein 3

RGS10 Gene

Oligodendrocyte-Myelin Dysfunction Hypothesis in Parkinson's Disease

RRAGA — Ras-Related GTP Binding A

DVL2 — Dishevelled Segment Polarity Protein 2

DEPTOR

DEPDC5-Related Epilepsy

DRD1 Gene

DVL1 Gene

RGS7 Gene

RGS6 Gene

MAPK1 Gene

Oligodendrocyte-Myelin Dysfunction Validation in Parkinson's Disease

DVL1 Protein

Datasets Dashboard

DEPDC5 Protein

RGS7 Protein

RPTOR Protein

Dishevelled 3 Protein

Outgoing (6)

Incoming (0)

Targeting Hypotheses (22)

Mentioning Analyses (15)

What molecular mechanisms explain how apoE promotes cerebral amyloid angiopathy

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

Why does autophagy inhibition improve neuronal survival when autophagy is typica

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

How does HDAC1/2 deletion specifically enhance microglial amyloid phagocytosis c

Can TREM2 receptor switching from agonism to antagonism be achieved safely witho

Why do structurally diverse sugars (trehalose, melibiose, lactulose) produce ide

What determines the spatial organization of autophagy receptors at stress granul

What determines the specificity of calcium-dependent PPP3/calcineurin activation

What is the optimal therapeutic window timing for autophagy enhancement versus s

How does TRIM21-mediated K63 ubiquitination of G3BP1 mechanistically inhibit liq

How do pathological stress granules in neurodegeneration escape TRIM21/autophagy

Human connectome alterations and network-level dysfunction in Alzheimer disease

Related Papers (20)