| Gene Symbol | AXLPROTEIN |
| Protein Type | Receptor |
| Function | is a member of the TAM (TYRO3, AXL, MERTK) receptor tyrosine kinase family that plays versatile roles in both normal physiology and disease pathogenesis. |
| Primary Expression | neurons, microglia, astrocytes, and vascular endothelial cells |
| Subcellular Localization | ** | Cell membrane, Endosomes, Nucleus | |
| Molecular Weight | 140 kDa |
| GeneCards | AXLPROTEIN |
| Human Protein Atlas | AXLPROTEIN |
| Proline-rich region | N-terminal segment |
| Single-pass α-helical membrane span | Connects extracellular and intracellular domains |
| Tyrosine kinase domain | Catalytic domain with ATP-binding pocket |
| Activation loop | Contains key tyrosine phosphorylation sites (Tyr821, Tyr824, Tyr866) |
| Multiple tyrosine residues | Sites for autophosphorylation and SH2 domain recruitment |
| Dimerization required | AXL exists as monomers that dimerize upon ligand binding |
| Kinase activity | Ligand-induced dimerization triggers autophosphorylation |
| Associated Diseases | Aging, Alzheimer, Cancer, INFLAMMATION, Ms, NEUROINFLAMMATION |
| Interactions | ADAM10, AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND |
| KG Connections | 202 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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