| Gene Symbol | BMP4 |
| Aliases | BMP4PROTEIN |
| Function | encodes a member of the TGF-beta superfamily of signaling molecules. |
| Subcellular Localization | </strong></td><td>Secreted; extracellular matrix-associated</td></tr> |
| Molecular Weight | 47 kDa |
| Amino Acids | 116 aa |
| Pathways | MAPK Pathway, PI3K, TGF-β |
| Ensembl ID | ENSG00000109475 |
| GeneCards | BMP4 |
| Human Protein Atlas | BMP4 |
| Noggin | High-affinity BMP4 antagonist that blocks both type I and type II receptor binding sites; critical for neural induction (Noggin expression in Spemann organizer) |
| Chordin | Binds BMP4 and sequesters it in inactive complexes; cleaved by BMP1/Tolloid metalloproteases to release active BMP4 |
| Follistatin | Binds BMP4 with moderate affinity; primarily associated with activin inhibition |
| Gremlin | BMP antagonist expressed in the CNS; modulates BMP4 signaling in adult neurogenic niches[@brewer2019] |
| TAK1-p38 MAPK | Promotes astrocyte differentiation and inflammatory responses |
| Associated Diseases | ALZHEIMER'S DISEASE, Cancer, Carcinoma, Ms, Tumor |
| Interactions | AND, APOE4, BMP7, HEDGEHOG, MICROGLIA, TGFB2 |
| KG Connections | 49 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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