Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BMP7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TGF-beta superfamily member with neuroprotective properties in Alzheimer's and Parkinson's disease
| Gene Symbol | BMP7 |
| Function | encodes a member of the TGF-beta superfamily of signaling molecules. |
| Primary Expression | adult tissues and has important roles in bone formation, kidney development, tissue repair, and neuroprotection |
| Amino Acids | 431 aa |
| Pathways | MAPK pathway, PI3K |
| Ensembl ID | ENSG00000101144 |
| GeneCards | BMP7 |
| Human Protein Atlas | BMP7 |
| Associated Diseases | Als, Alzheimer, Autoimmune, Cancer, Carcinoma, Diabetes |
| Interactions | TGFB2, BMP4, TGFBR1, ERK1, BMPR1B, ERK |
| KG Connections | 62 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
BMP7["<b>BMP7</b>"]
Ms{"Ms"}
BMP7 -->|"therapeutic target"| Ms
Tumor{"Tumor"}
BMP7 -->|"activates"| Tumor
Carcinoma{"Carcinoma"}
BMP7 -->|"associated with"| Carcinoma
BMP7 -->|"associated with"| Ms
Cancer{"Cancer"}
BMP7 -->|"associated with"| Cancer
BMP7 -->|"associated with"| Tumor
Hepatitis{"Hepatitis"}
BMP7 -->|"associated with"| Hepatitis
Glioblastoma{"Glioblastoma"}
BMP7 -->|"associated with"| Glioblastoma
Alzheimer{"Alzheimer"}
BMP7 -->|"associated with"| Alzheimer
Obesity{"Obesity"}
BMP7 -->|"associated with"| Obesity
Diabetes{"Diabetes"}
BMP7 -->|"associated with"| Diabetes
Stroke{"Stroke"}
BMP7 -->|"associated with"| Stroke
ERK["ERK"]
ERK -->|"activates"| BMP7
TGFBR2["TGFBR2"]
TGFBR2 -->|"associated with"| BMP7
BMP4["BMP4"]
BMP4 -->|"activates"| BMP7
MIRNAS["MIRNAS"]
MIRNAS -->|"associated with"| BMP7
MYC["MYC"]
MYC -->|"associated with"| BMP7
E2F5["E2F5"]
E2F5 -->|"associated with"| BMP7
CDKN2B["CDKN2B"]
CDKN2B -->|"associated with"| BMP7
TGFBR1["TGFBR1"]
TGFBR1 -->|"activates"| BMP7
CANCER["CANCER"]
CANCER -->|"associated with"| BMP7
BMP2["BMP2"]
BMP2 -->|"associated with"| BMP7
TGFB2["TGFB2"]
TGFB2 -->|"activates"| BMP7
RORA["RORA"]
RORA -->|"associated with"| BMP7
style BMP7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Astrocyte | regulates | cell_type | 0.80 |
| Ms | therapeutic_target | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Carcinoma | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| Hepatitis | associated_with | disease | 0.65 |
| Glioblastoma | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Obesity | associated_with | disease | 0.65 |
| Diabetes | associated_with | disease | 0.65 |
| Stroke | associated_with | disease | 0.65 |
| Multiple Sclerosis | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Fibrosis | associated_with | disease | 0.65 |
| Leukemia | associated_with | disease | 0.65 |
| Autoimmune | associated_with | disease | 0.65 |
| Obesity | inhibits | disease | 0.65 |
| CX3CR1 | associated_with | gene | 0.60 |
| AHR | associated_with | gene | 0.60 |
| EP300 | associated_with | gene | 0.60 |
| JUN | associated_with | gene | 0.60 |
| JAK2 | associated_with | gene | 0.60 |
| CCL20 | associated_with | gene | 0.60 |
| CD38 | associated_with | gene | 0.60 |
| FOXP3 | associated_with | gene | 0.60 |
| PPARG | associated_with | gene | 0.60 |
| NOTCH1 | associated_with | gene | 0.60 |
| SMAD6 | associated_with | gene | 0.60 |
| FOXP2 | associated_with | gene | 0.60 |
| GATA3 | associated_with | gene | 0.60 |
| ATF6 | associated_with | gene | 0.60 |
| MAF | associated_with | gene | 0.60 |
| TGFB2 | activates | gene | 0.60 |
| E2F5 | associated_with | gene | 0.60 |
| CDKN2B | associated_with | gene | 0.60 |
| CYTOKINES | associated_with | gene | 0.60 |
| DIABETES MELLITUS | associated_with | gene | 0.60 |
| MICRORNAS | associated_with | gene | 0.60 |
| ALZHEIMER DISEASE | associated_with | gene | 0.60 |
| Notch | associated_with | pathway | 0.60 |
| Differentiation | inhibits | pathway | 0.60 |
| GENES | associated_with | gene | 0.60 |
| MIRNAS | associated_with | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TGFBR2 | associated_with | gene | 0.60 |
| BMP4 | activates | gene | 0.60 |
| MYC | associated_with | gene | 0.60 |
| E2F5 | associated_with | gene | 0.60 |
| CDKN2B | associated_with | gene | 0.60 |
| TGFBR1 | activates | gene | 0.60 |
| BMP2 | associated_with | gene | 0.60 |
| TGFB2 | activates | gene | 0.60 |
| RORA | associated_with | gene | 0.60 |
| ERK1 | inhibits | gene | 0.60 |
| BMPR1B | activates | gene | 0.60 |
| ERK | activates | gene | 0.60 |
| MIRNAS | associated_with | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| ERK | inhibits | gene | 0.60 |
| AND | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||