gene

BMP7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BMP7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

62Connections
0Hypotheses
0Analyses
46Outgoing
16Incoming

Summary

TGF-beta superfamily member with neuroprotective properties in Alzheimer's and Parkinson's disease

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🧬 Gene Info
Gene SymbolBMP7
Functionencodes a member of the TGF-beta superfamily of signaling molecules.
Primary Expressionadult tissues and has important roles in bone formation, kidney development, tissue repair, and neuroprotection
Amino Acids431 aa
PathwaysMAPK pathway, PI3K
Ensembl IDENSG00000101144
GeneCardsBMP7
Human Protein AtlasBMP7
Associated DiseasesAls, Alzheimer, Autoimmune, Cancer, Carcinoma, Diabetes
InteractionsTGFB2, BMP4, TGFBR1, ERK1, BMPR1B, ERK
KG Connections62 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (20)

Knowledge base pages for this entity

Canonical Page

BMP7 Gene (Bone Morphogenetic Protein 7)

gene · 1147 words

BMPR2 Gene

gene · 2573 words

SMAD5 — SMAD Family Member 5

gene · 2466 words

BMPR1A — Bone Morphogenetic Protein Receptor Type 1A

gene · 2382 words

Adult Hippocampal Neurogenesis: Impaired in Alzheimer's Disease, Enhanced in Superagers

mechanism · 2362 words

ACVR1 Gene

gene · 2349 words

Pathway Diagram

graph TD
    BMP7["<b>BMP7</b>"]
    Ms{"Ms"}
    BMP7 -->|"therapeutic target"| Ms
    Tumor{"Tumor"}
    BMP7 -->|"activates"| Tumor
    Carcinoma{"Carcinoma"}
    BMP7 -->|"associated with"| Carcinoma
    BMP7 -->|"associated with"| Ms
    Cancer{"Cancer"}
    BMP7 -->|"associated with"| Cancer
    BMP7 -->|"associated with"| Tumor
    Hepatitis{"Hepatitis"}
    BMP7 -->|"associated with"| Hepatitis
    Glioblastoma{"Glioblastoma"}
    BMP7 -->|"associated with"| Glioblastoma
    Alzheimer{"Alzheimer"}
    BMP7 -->|"associated with"| Alzheimer
    Obesity{"Obesity"}
    BMP7 -->|"associated with"| Obesity
    Diabetes{"Diabetes"}
    BMP7 -->|"associated with"| Diabetes
    Stroke{"Stroke"}
    BMP7 -->|"associated with"| Stroke
    ERK["ERK"]
    ERK -->|"activates"| BMP7
    TGFBR2["TGFBR2"]
    TGFBR2 -->|"associated with"| BMP7
    BMP4["BMP4"]
    BMP4 -->|"activates"| BMP7
    MIRNAS["MIRNAS"]
    MIRNAS -->|"associated with"| BMP7
    MYC["MYC"]
    MYC -->|"associated with"| BMP7
    E2F5["E2F5"]
    E2F5 -->|"associated with"| BMP7
    CDKN2B["CDKN2B"]
    CDKN2B -->|"associated with"| BMP7
    TGFBR1["TGFBR1"]
    TGFBR1 -->|"activates"| BMP7
    CANCER["CANCER"]
    CANCER -->|"associated with"| BMP7
    BMP2["BMP2"]
    BMP2 -->|"associated with"| BMP7
    TGFB2["TGFB2"]
    TGFB2 -->|"activates"| BMP7
    RORA["RORA"]
    RORA -->|"associated with"| BMP7
    style BMP7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (46)

TargetRelationTypeStr
Astrocyteregulatescell_type0.80
Mstherapeutic_targetdisease0.65
Tumoractivatesdisease0.65
Carcinomaassociated_withdisease0.65
Msassociated_withdisease0.65

Incoming (16)

SourceRelationTypeStr
TGFBR2associated_withgene0.60
BMP4activatesgene0.60
MYCassociated_withgene0.60
E2F5associated_withgene0.60
CDKN2Bassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found