concept

HEDGEHOG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HEDGEHOG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

431Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	HEDGEHOG
Key Genes/Proteins	ACETYL-COA, Actin, ADCY3, AGING, Akt, ALS
Related Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Hedgehog Signaling Pathway in Neurodegeneration

mechanism · 2948 words

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Pathway Diagram

graph TD
    HEDGEHOG["HEDGEHOG"]
    HEDGEHOG -->|"interacts"| Tgf__["Tgf-Beta"]
    HEDGEHOG -->|"interacts"| Autophagy["Autophagy"]
    HEDGEHOG -->|"interacts"| Oxidative_Stress["Oxidative Stress"]
    HEDGEHOG -->|"interacts"| Notch["Notch"]
    HEDGEHOG -->|"interacts"| Epigenetic["Epigenetic"]
    HEDGEHOG -->|"interacts"| Mtor["Mtor"]
    LIF["LIF"] -->|"activates"| HEDGEHOG
    EGFR["EGFR"] -->|"activates"| HEDGEHOG
    BNIP3["BNIP3"] -->|"activates"| HEDGEHOG
    BECN1["BECN1"] -->|"activates"| HEDGEHOG
    ATG7["ATG7"] -->|"activates"| HEDGEHOG
    GLI1["GLI1"] -->|"activates"| HEDGEHOG
    BCL2["BCL2"] -->|"activates"| HEDGEHOG
    Leukemia["Leukemia"] -->|"activates"| HEDGEHOG
    Cancer["Cancer"] -->|"activates"| HEDGEHOG
    Tumor["Tumor"] -->|"activates"| HEDGEHOG

Outgoing (118)

Target	Relation	Type	Str
Cancer	regulates	disease	0.65
Als	activates	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Als	regulates	disease	0.65
Leukemia	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Tgf-Β	contributes_to	pathway	0.60
MTOR	regulates	gene	0.60
Mtor	regulates	pathway	0.60
GENES	regulates	gene	0.60
Pi3K	associated_with	protein	0.60
HDAC	therapeutic_target	gene	0.60
Notch	contributes_to	pathway	0.60
Wnt	contributes_to	pathway	0.60
Macrophage	associated_with	cell_type	0.60
Il-6	associated_with	protein	0.60
Stat3	associated_with	protein	0.60
Akt	associated_with	protein	0.60
Ras	associated_with	protein	0.60
Chemokine	activates	protein	0.60
Interleukin	activates	protein	0.60
Cytokine	activates	protein	0.60
Rb	activates	protein	0.60
NOTCH	associated_with	gene	0.60
CD163	associated_with	gene	0.60
STAT5B	associated_with	gene	0.60
PFKFB3	associated_with	gene	0.60
PD-L1	associated_with	gene	0.60
Nf-Κb	associated_with	pathway	0.60
Pi3K/Akt	associated_with	pathway	0.60
T Cell	associated_with	cell_type	0.60
Epithelial	associated_with	cell_type	0.60
Collagen	therapeutic_target	protein	0.60
HDAC	associated_with	gene	0.60
LIF	activates	gene	0.60
CANCER	activates	gene	0.60
HIPPO	activates	gene	0.60
Astrocyte	associated_with	cell_type	0.60

Incoming (313)

Source	Relation	Type	Str
CANCER	therapeutic_target	gene	0.90
Cancer	therapeutic_target	disease	0.90
Als	therapeutic_target	disease	0.90
CANCER	regulates	gene	0.80
Tumor	therapeutic_target	disease	0.80
SMO	therapeutic_target	gene	0.80
Als	regulates	disease	0.80
SHH	associated_with	gene	0.80
Inflammation	therapeutic_target	disease	0.70
HIPPO	regulates	gene	0.70
MIRNAS	regulates	gene	0.70
INFLAMMATION	therapeutic_target	gene	0.70
CANCER	associated_with	gene	0.70
Carcinoma	therapeutic_target	disease	0.70
APOPTOSIS	regulates	gene	0.70
RUNX2	regulates	gene	0.70
GLI1	activates	gene	0.70
AKT	associated_with	gene	0.70
PI3K	associated_with	gene	0.70
Cancer	associated_with	disease	0.70
Autoimmune	therapeutic_target	disease	0.70
BCL2	activates	gene	0.70
Tumor	activates	disease	0.70
NF-ΚB	interacts_with	gene	0.70
CANCER	inhibits	gene	0.70
AKT	activates	gene	0.70
PARKINSON'S DISEASE	activates	gene	0.70
Cancer	regulates	disease	0.70
Cancer	inhibits	disease	0.70
APOPTOSIS	activates	gene	0.70
SHH	activates	gene	0.70
SHH	regulates	gene	0.70
LRRK2	activates	gene	0.60
PTEN	activates	gene	0.60
PINK1	activates	gene	0.60
ERK	activates	gene	0.60
JAK	activates	gene	0.60
PI3K	activates	gene	0.60
NF-ΚB	activates	gene	0.60
NATURAL COMPOUNDS	therapeutic_target	gene	0.60
P38	therapeutic_target	gene	0.60
C-JUN	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
SHH	interacts_with	gene	0.60
P53	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
GBM	interacts_with	gene	0.60
LMNA	inhibits	gene	0.60
CANCER	expressed_in	gene	0.60
MTOR	expressed_in	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Sonic hedgehog pathway compartmentalization as quantitative	0.485	neuroscience	How can subcellular compartmentalization

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HEDGEHOG in their description or question text

No additional research found