| Gene Symbol | CALM2 |
| Protein Family | EF-hand calcium-binding protein family |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | Cytoplasm, Nucleus |
| Amino Acids | 148 aa |
| Exons | 6 |
| Pathways | Autophagy, Cell Cycle, Immune Response, Mtor |
| Ensembl ID | ENSG00000101444 |
| GeneCards | CALM2 |
| Human Protein Atlas | CALM2 |
| Four EF-hand Domains | Each EF-hand consists of a conserved 12-residue loop flanked by two α-helices (E and F helices) |
| N-terminal Domain | Contains EF-hands 1 and 2, with lower Ca²⁺ affinity |
| C-terminal Domain | Contains EF-hands 3 and 4, with higher Ca²⁺ affinity |
| Central Linker | Flexible linker allows conformational changes upon Ca²⁺ binding |
| CaMKII/IV | Calcium/calmodulin-dependent protein kinases critical for synaptic plasticity |
| Associated Diseases | neurodegeneration |
| KG Connections | 59 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |