gene 1,242 words KG: IL6R
Contents

IL6R Gene

🧬 Gene Info
Gene SymbolIL6R
Full NameInterleukin 6 Receptor
Chromosome1q21.3
Protein TypeReceptor
FunctionIL-6R is a type I cytokine receptor that exists in both membrane-bound and soluble forms, mediating IL-6 signaling through multiple pathways:
Molecular Weight~50 kDa (mIL-6R), ~55 kDa (sIL-6R)
Amino Acids468 aa
Exons10
PathwaysMAPK, PI3K
UniProt IDP08887
NCBI Gene ID3570
Ensembl IDENSG00000160712
OMIM147610
GeneCardsIL6R
Human Protein AtlasIL6R
Associated DiseasesCancer, Carcinoma, Cardiovascular, Hepatitis, Pneumonia, bacterial_infections
InteractionsSTAT3, IL6ST, STAT1, STING, IL6, IL22
KG Connections149 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (2)

APOE-Dependent Autophagy Restoration
Score: 0.61
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59

Related Analyses (2)

Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (11)

Brain Connectivity-Targeted tACS Trial in Early AD
clinical · proposed · Score: 0.95
s:** - Test whether HCN1 knockout specifically in EC layer I
falsification · proposed · Score: 0.40
AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Posi
clinical · proposed · Score: 0.40
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau
clinical · proposed · Score: 0.40
Biomarker-Guided Sequential Therapy Selection in Alzheimer's
clinical · proposed · Score: 0.40

See Also (10)

Packard Center for ALS Research
institution · KG edge: inhibits
IL22
gene · KG edge: associated_with
HNF4A - Hepatocyte Nuclear Factor 4 Alpha
gene · KG edge: activates
CDKN1A — Cyclin-Dependent Kinase Inhibitor 1A
gene · KG edge: regulates
CALM2 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

IL6R regulates STROKE
IL6R associated_with bacterial_infections
IL6R associated_with IL6
IL6R activates STAT3
IL6R interacts_with IL6ST
IL6R activates STAT1
IL6R activates STING
IL6R inhibits IL6
IL6R associated_with MMP12
IL6R regulates MERTK