gene 1,116 words KG: LITAF 2026-03-29
kind:genesection:genesstate:published
Contents

LITAF — Lipopolysaccharide-Induced Tumor Necrosis Factor Factor

🧬 Gene Info
Gene SymbolLITAF
Full NameLipopolysaccharide-Induced Tumor Necrosis Factor Factor
AliasesSIMPLE, CMT1C
Chromosome16p13.13
FunctionThe protein contains several functional domains
Subcellular Localizationthe lysosomal membrane and late endosome compartments. The protein contains several functional domains:
Molecular Weight17 kDa
Amino Acids161 aa
PathwaysAutophagy, Cell Cycle, Immune Response, Mtor
UniProt IDQ9Y5K2
NCBI Gene ID10868
Ensembl IDENSG00000106789
OMIM604577
GeneCardsLITAF
Human Protein AtlasLITAF
Associated DiseasesALS, Alzheimer's disease, frontotemporal dementia
InteractionsSOX2, IRF1, SOX9, NFKBIA, JUN, Nfkb
KG Connections75 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (3)

Senescence-Induced Lipid Peroxidation Spreading
Score: 0.53
Lysosomal Positioning Dynamics Modulation
Score: 0.43
Extracellular Vesicle Biogenesis Modulation
Score: 0.34

Related Analyses (2)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (13)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: regulates
MERTK - MER Tyrosine Kinase
gene · KG edge: regulates
JUN Gene
gene · KG edge: activates
IRF1 Gene - Interferon Regulatory Factor 1
gene · KG edge: activates
il6r
gene · KG edge: regulates

Knowledge Graph (12 edges)

LITAF regulates IL6R
LITAF regulates MERTK
LITAF regulates DUSP1
LITAF regulates ADCY9
LITAF activates SOX2
LITAF regulates CDKN1A
LITAF regulates SESN1
LITAF activates IRF1
LITAF regulates NDRG2
LITAF activates SOX9