gene 2,724 words KG: PDK4
Contents

PDK4 (3-Phosphoinositide-Dependent Protein Kinase-4)

🧬 Gene Info
Gene SymbolPDK4
Chromosome7q21.3
Protein TypeKinase
Functionis a member of the phosphoinositide-dependent protein kinase (PDK) family that plays critical roles in regulating cellular metabolism, mitochondrial function, and survival.
Primary Expressiontissues with high metabolic demand, including heart, skeletal muscle, and brain
Amino Acids404 aa
Exons10
PathwaysAutophagy, Cell Cycle, Immune Response, Mtor
Ensembl IDENSG00000101447
GeneCardsPDK4
Human Protein AtlasPDK4
Associated DiseasesMs
InteractionsFERROPTOSIS, UBIQUITIN
KG Connections95 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (23)

Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
APOE-Dependent Autophagy Restoration
Score: 0.61

Related Analyses (7)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
CRISPR Gene Correction Approaches for CBS/PSP
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (15)

Packard Center for ALS Research
institution · KG edge: inhibits
Transdiagnostic Proteomic Changes in Neurodegeneration
gene · KG edge: associated_with
NPY1R Gene
gene · KG edge: regulates
NFKBIA Gene (NFKB Inhibitor Alpha)
gene · KG edge: regulates
MERTK - MER Tyrosine Kinase
gene · KG edge: regulates

Knowledge Graph (12 edges)

PDK4 associated_with SOD1
PDK4 associated_with TNFR2
PDK4 associated_with BCL2
PDK4 associated_with SLC16A1
PDK4 regulates LITAF
PDK4 regulates IL6R
PDK4 regulates MERTK
PDK4 regulates DUSP1
PDK4 regulates ADCY9
PDK4 regulates SOX2