gene 2,621 words KG: MERTK 2026-03-26
kind:genesection:genestopic:alzheimerstopic:parkinsonstopic:neuroinflammation
Contents

MERTK - MER Tyrosine Kinase

🧬 Gene Info
Gene SymbolMERTK
Full NameMERTK - MER Tyrosine Kinase
AliasesPage for MERTK Protein
Chromosome2q14.1
Protein TypeGene
Primary Expressionmacrophages, microglia, photoreceptor cells, and neurons, where it mediates the clearance of apoptotic cells and cellular debris through recognition o
Molecular Weight110 kDa
Amino Acids998 aa
Exons20
PathwaysNF-κB, PI3K, MAPK
UniProt IDQ12866
NCBI Gene ID10488
Ensembl IDENSG00000153208
GeneCardsMERTK
Human Protein AtlasMERTK
Associated DiseasesAging, Alzheimer, Diabetes, Fibrosis, Hepatitis, Infection
InteractionsAKT, MAF, SIRPA, MTOR, GPR109A, TREM2
KG Connections254 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

APOE-Dependent Autophagy Restoration
Score: 0.61
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Complement C1q Mimetic Decoy Therapy
Score: 0.48
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.45
Complement C1q Subtype Switching
Score: 0.44

Related Analyses (4)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
ALDH1L1
gene · KG edge: expressed_in
ADRA1D Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

MERTK activates AKT
MERTK activates MAF
MERTK expressed_in GFAP
MERTK expressed_in ALDH1L1
MERTK expressed_in STAT6
MERTK expressed_in EPHA4
MERTK mediates Efferocytosis
MERTK activates SIRPA
MERTK regulates DUSP1
MERTK regulates ADCY9