protein 773 words KG: PPP5C 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

PPP5C Protein

🔬 Protein Info
Gene SymbolPPP5C
Protein FamilySerine/Threonine Phosphatase Family
Protein TypeSerine/Threonine Phosphatase
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionvarious cancers - Cell Proliferation: Promotes cell cycle progression - Therapeutic Target: PP5 inhibitors are being explored as cancer therap
Subcellular LocalizationCytoplasm, Nucleus
Molecular Weight57 kDa
Amino Acids589 aa
PathwaysMAPK
UniProt ID[P62937](https://www.uniprot.org/uniprot/P62937)
Ensembl IDENSG00000111454
GeneCardsPPP5C
Human Protein AtlasPPP5C
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsTPR, CCND1, SESN1, CDKN1A, NDRG2, DUSP1
KG Connections63 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (4)

HSP90-Tau Disaggregation Complex Enhancement
Score: 0.44
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (14)

PDK4 (3-Phosphoinositide-Dependent Protein Kinase-4)
gene · KG edge: regulates
NPY1R Gene
gene · KG edge: regulates
NFKBIA Gene (NFKB Inhibitor Alpha)
gene · KG edge: regulates
NDRG2 — N-myc Downstream Regulated Gene 2
gene · KG edge: interacts_with
MYH2 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

PPP5C regulates JUN
PPP5C regulates ADRA1D
PPP5C regulates PDK4
PPP5C regulates LITAF
PPP5C regulates IL6R
PPP5C regulates MERTK
PPP5C regulates DUSP1
PPP5C regulates ADCY9
PPP5C regulates SOX2
PPP5C regulates CDKN1A