| Gene Symbol | CCL2 |
| Aliases | CCL2PROTEIN |
| Chromosome | 17q12 |
| Primary Expression | blood-brain barrier, spinal cord, Cerebellum, Spinal Cord |
| Subcellular Localization | </strong> Secreted (extracellular)</div> |
| Molecular Weight | 9.9 kDa |
| Amino Acids | 99 aa |
| Pathways | NF-κB |
| GeneCards | CCL2 |
| Human Protein Atlas | CCL2 |
| Promoter elements | Contains binding sites for NF-κB, AP-1, and other transcription factors responsive to inflammatory stimuli |
| Tissue-specific expression | Constitutively expressed at low levels in many tissues; dramatically upregulated by pro-inflammatory cytokines |
| Alternative splicing | Produces multiple splice variants with potentially distinct functions |
| N-terminal region | Contains the receptor-binding site; critical for receptor activation |
| Core domain | Consists of a beta-sheet with three anti-parallel strands |
| Associated Diseases | ALS, Alzheimer, Cancer, Chronic Obstructive Pulmonary Disease, Inflammation |
| Known Drugs/Compounds | METFORMIN, metformin |
| Interactions | INFLAMMATION, NEURODEGENERATION, ASTROCYTE, LRP1, CANCER, ERCC3 |
| KG Connections | 878 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |