protein

metformin

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about metformin: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

581Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	metformin
NCT Number	NCT07055958
Title	Metformin Add-on Therapy for Parkinson's Disease
Status	Recruiting
Phase	Phase II
Condition(s)	Parkinson's Disease
Intervention	Metformin hydrochloride 500mg twice daily + standard Levodopa/Carbidopa
Sponsor	Bangabandhu Sheikh Mujib Medical University, Bangladesh
Location	Dhaka, Bangladesh
Enrollment	60 patients (estimated)
Study Duration	52 weeks
Known Drugs/Compounds	AMPK, Parkinson's disease, Alzheimer's disease, type 2 diabetes mellitus, reactive oxygen species production, epilepsy
KG Connections	95 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    metformin["metformin"] -.->|"inhibits"| astrocyte_senescence["astrocyte senescence"]
    style astrocyte_senescence fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    metformin["metformin"] -->|"treats"| insulin_sensitivity["insulin sensitivity"]
    style insulin_sensitivity fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    metformin["metformin"] -->|"regulates"| mitochondrial_function["mitochondrial function"]
    style mitochondrial_function fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    metformin["metformin"] -->|"treats"| diabetes["diabetes"]
    style diabetes fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    metformin["metformin"] -.->|"suppresses"| MCOLN1["MCOLN1"]
    style MCOLN1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    metformin["metformin"] -->|"prevents"| dopamine_neuron_injury["dopamine neuron injury"]
    style dopamine_neuron_injury fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    metformin["metformin"] -->|"activates"| PRKAA2["PRKAA2"]
    style PRKAA2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style metformin fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (380)

Target	Relation	Type	Str
astrocyte senescence	inhibits	process	0.95
insulin sensitivity	treats	phenotype	0.90
mitochondrial function	regulates	process	0.90
MCOLN1	suppresses	gene	0.90
dopamine neuron injury	prevents	phenotype	0.88
PRKAA2	activates	gene	0.85
Drug-Induced Lung Injury	treats	disease	0.85
autophagosome-lysosome fusion	associated_with	process	0.85
AMPK	activates	protein	0.80
AMPK	targets	gene	0.80
BMAL1	regulates	gene	0.70
Parkinson's disease	treats	disease	0.70
Alzheimer's disease	treats	disease	0.70
type 2 diabetes mellitus	treats	disease	0.70
reactive oxygen species production	inhibits	process	0.70
epilepsy	treats	disease	0.70
SIRT1	targets	gene	0.70
PRKAA1	targets	gene	0.70
PPARGC1A	targets	gene	0.70
NAD+ metabolism	modulates	pathway	0.65
Alzheimer's disease	therapeutic_target	disease	0.60
DNM1L	targets	gene	0.60
ATP	targets	gene	0.60
GLI1	targets	gene	0.60
METTL3	targets	gene	0.60
GFAP	targets	gene	0.60
PI3K	targets	gene	0.60
PKC	targets	gene	0.60
AND	targets	gene	0.60
DNA	targets	gene	0.60
TREM2	targets	gene	0.60
SYK	targets	gene	0.60
TNC	targets	gene	0.60
NLRP3	targets	gene	0.60
BDNF	targets	gene	0.60
STING	targets	gene	0.60
LKB1	targets	gene	0.60
CNTF	targets	gene	0.60
MOG	targets	gene	0.60
MBP	targets	gene	0.60
NGF	targets	gene	0.60
multiple sclerosis	treats	disease	0.60
TLR	targets	gene	0.60
MAPK	targets	gene	0.60
TNF	targets	gene	0.60
EGR1	targets	gene	0.60
ERK	targets	gene	0.60
CDK5	targets	gene	0.60
HG	targets	gene	0.60
GLI	targets	gene	0.60

Incoming (201)

Source	Relation	Type	Str
PRKAA1	therapeutic_target	gene	0.90
PRKAA2	therapeutic_target	gene	0.90
AMPK	treats	gene	0.65
ENDOTHELIAL	causes	cell_type	0.65
DIABETES	contributes_to	disease	0.65
CA1	protects_against	brain_region	0.65
GFAP	protects_against	gene	0.65
ALZHEIMER	treats	disease	0.65
ALZHEIMER'S DISEASE	treats	disease	0.65
DIABETES	treats	disease	0.65
BDNF	promotes	gene	0.65
CGAS	mediates	gene	0.65
SYK	regulates	gene	0.65
HEPATOCYTES	treats	cell_type	0.65
DIABETES	targets	disease	0.65
TREM2	protects_against	gene	0.65
TH	causes	gene	0.65
NICOTINAMIDE	activates	drug	0.65
NICOTINAMIDE	treats	drug	0.65
MLKL	inhibits	gene	0.65
MLKL	activates	gene	0.65
NEURONS	treats	cell_type	0.65
CYTOKINES	inhibits	phenotype	0.65
TNF	inhibits	gene	0.65
OXIDATIVE STRESS	regulates	phenotype	0.65
COGNITIVE DECLINE	activates	phenotype	0.65
AMYLOID PLAQUES	protects_against	phenotype	0.65
PARKINSON'S DISEASE	targets	disease	0.65
AKT	regulates	gene	0.65
CCL2	inhibits	gene	0.65
AMPK	implicated_in	gene	0.55
AMPK	participates_in	gene	0.55
PARKINSON'S DISEASE	participates_in	disease	0.55
AUTOPHAGY	activates	process	0.50
AMPK	upregulates	gene	0.50
SIRT1	upregulates	gene	0.50
INFLAMMATION	associated_with	process	0.50
T CELL	inhibits	cell_type	0.50
AGING	protects_against	process	0.50
AGING	inhibits	process	0.50
TREM2	inhibits	gene	0.50
NEUROINFLAMMATION	inhibits	process	0.50
TREM2	regulates	gene	0.50
NEUROINFLAMMATION	regulates	process	0.50
NLRP3	activates	gene	0.50
MICROGLIA	activates	cell_type	0.50
TREM2	activates	gene	0.50
AMPK	activates	gene	0.50
SIRT1	activates	gene	0.50
SIRT1	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Why does Metformin fail to delay CJD progression despite improving anti-aging ha

neurodegeneration | 2026-04-14 | 0 hypotheses

Metabolic reprogramming in neurodegenerative disease

neurodegeneration | 2026-04-02 | 3 hypotheses Top: 0.398

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

metformin

Understanding Entity Pages

Wiki Pages (21)

metformin-add-on-levodopa-pd-nct07055958

cbs-psp-daily-action-plan

Parkinson's Disease

CBS/PSP Supplements Guide

Corticobasal Degeneration (CBD)

Neuroresilience Mechanisms and Evidence

Therapeutics

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

CBS/PSP Treatment Rankings

Mitochondrial Quality Control

Mitochondrial Dysfunction in Parkinson's Disease

Autophagy Mechanisms

Mitophagy Pathway in Neurodegeneration

Vascular Cognitive Impairment (VCI)

Synaptic Vesicle Trafficking in Parkinson's Disease

nlrc5-protein

Mitochondrial Dysfunction in Neurodegeneration

Synucleinopathies

Gene-Mechanism-Therapy Causal Chains

Insulin Signaling in Parkinson's Disease

creatine-supplementation-neurodegeneration