| Gene Symbol | CD40 |
| Full Name | Cluster of Differentiation 40 |
| Aliases | CD40PROTEIN |
| Chromosome | 20q12 |
| Protein Family | TNF receptor superfamily |
| Function | CD40-CD40L signaling is central to immune function |
| Primary Expression | AD brain by microglia and astrocytes
- CD40-CD40L interaction promotes:
- Microglial activation
- Pro-i |
| Molecular Weight | 48 kDa |
| Amino Acids | 277 aa |
| Exons | 9 |
| Pathways | NF-κB, MAPK pathway, PI3K |
| GeneCards | CD40 |
| Human Protein Atlas | CD40 |
| Approach | Status |
| CD40-Fc fusion | Preclinical |
| Associated Diseases | AD, ALI, Autoimmune, Cancer, Ms, RA |
| Interactions | FOSB, EGF, VEGF, CD8, NOTCH1, MCL1 |
| KG Connections | 103 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |