| Gene Symbol | CLDN5PROTEIN |
| Full Name | Claudin-5 Protein |
| Protein Family | Claudin family |
| Target Class | Structural Protein |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Mechanism of Action | Tight junction protein modulation - no established druggable mechanisms |
| Subcellular Localization | Tight junctions of brain endothelial cells |
| Druggability | Undruggable (0.20) |
| Clinical Stage | Approved |
| Molecular Weight | 21.8 kDa |
| UniProt ID | O00511 |
| GeneCards | CLDN5PROTEIN |
| Human Protein Atlas | CLDN5PROTEIN |
| Protein Name | Claudin-5 Protein |
| Gene | CLDN5 |
| Associated Diseases | ALS, Brain Edema, Stroke, blood-retinal barrier integrity, neurodegeneration |
| Known Drugs/Compounds | curcumin, resveratrol |
| Interactions | OCLN, CAV1, HIF1A, IL23A, BECN1, IL6 |
| SciDEX Target | View Target Profile (5 clinical trials) |
| SciDEX Hypotheses | Vascular-Glial Interface Restoration |
| KG Connections | 381 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |