concept

CURCUMIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CURCUMIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

405Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

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💡 Concept Info

Name	CURCUMIN
Key Genes/Proteins	ACSL4, AKT, AMPK, AMYLOID, AMYLOID-BETA, aplp1
Related Diseases	ACETYLCHOLINE, aging, AGING, ALZHEIMER, Alzheimer'S Disease

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Curcumin for Neurodegeneration

therapeutic · 4017 words

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Pathway Diagram

graph TD
    CURCUMIN["CURCUMIN"]
    CURCUMIN -->|"treats"| Gastric_Cancer["Gastric Cancer"]
    CURCUMIN -->|"activates"| Ferroptosis["Ferroptosis"]
    CURCUMIN -->|"activates"| Autophagy["Autophagy"]
    CURCUMIN -->|"inhibits"| PI3K_AKT_mTOR_Signaling_Pathwa["PI3K/AKT/mTOR Signaling Pathway"]
    CURCUMIN -->|"inhibits"| Inflammation["Inflammation"]
    CURCUMIN -->|"inhibits"| Oxidative_Stress["Oxidative Stress"]
    CURCUMIN -->|"treats"| Intestinal_Barrier_Injury["Intestinal Barrier Injury"]
    CURCUMIN -->|"inhibits"| reactive_oxygen_species["reactive oxygen species"]
    Ampk_Tfeb["Ampk-Tfeb"] -->|"mediates"| CURCUMIN
    APOPTOSIS["APOPTOSIS"] -->|"activates"| CURCUMIN
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| CURCUMIN
    AGING["AGING"] -->|"activates"| CURCUMIN
    CANCER["CANCER"] -->|"activates"| CURCUMIN
    ATG5["ATG5"] -->|"activates"| CURCUMIN
    ATG7["ATG7"] -->|"activates"| CURCUMIN

Outgoing (272)

Target	Relation	Type	Str
Gastric Cancer	treats	disease	0.95
Oxidative Stress	associated_with	process	0.95
Ferroptosis	activates	process	0.94
Autophagy	activates	process	0.93
PI3K/AKT/mTOR Signaling Pathway	inhibits	pathway	0.92
Oxidative Stress	inhibits	process	0.90
Inflammation	inhibits	process	0.90
STAT3	inhibits	gene	0.90
Intestinal Barrier Injury	treats	disease	0.90
JAK2	inhibits	gene	0.90
STAT1	inhibits	gene	0.90
reactive oxygen species	inhibits	process	0.90
Mitochondrial Damage	associated_with	disease	0.90
IL-17/NF-κB Signaling Pathway	inhibits	pathway	0.88
Rheumatoid Arthritis	treats	disease	0.85
MMP9	targets	protein	0.85
NF-KB	modulates	gene	0.85
Neuroinflammation	inhibits	process	0.85
AMPK	activates	protein	0.85
neuroinflammation	associated_with	process	0.85
STAT6	activates	gene	0.85
mitochondrial dysfunction	associated_with	process	0.85
neural mitochondrial dysfunction	associated_with	process	0.85
Spinal Cord Injury	treats	disease	0.85
BECN1	upstream_of	gene	0.85
Cell Apoptosis	associated_with	process	0.82
AKT	activates	protein	0.80
NEURODEGENERATION	protects_against	disease	0.80
Apoptotic Pathways	modulates	pathway	0.80
PI3K	activates	pathway	0.80
Parkinson's Disease	treats	disease	0.80
PI3K/Akt signaling	activates	pathway	0.80
OPRL1	downregulates	gene	0.80
Mitochondrial Dysfunction	modulates	process	0.80
Healthy Aging	associated_with	phenotype	0.80
Neurodegeneration	protects_against	disease	0.80
BDNF	activates	protein	0.80
Cognitive Function	protects_against	phenotype	0.80
SOCS1	upregulates	gene	0.80
Age-Related Disorders	treats	disease	0.80
Apoptosis	modulates	process	0.75
NAMPT/NAD+ pathway	activates	pathway	0.75
KL	modulates	gene	0.75
ALZHEIMER'S DISEASE	treats	disease	0.70
aging	treats	disease	0.70
neurogenesis	activates	process	0.70
cell apoptosis	inhibits	process	0.70
apoptosis	regulates	process	0.70
PI3K/AKT/mTOR	regulates	pathway	0.70
Muscle Health	protects_against	phenotype	0.70

Incoming (133)

Source	Relation	Type	Str
Ampk-Tfeb	mediates	pathway	0.80
ALZHEIMER	treats	disease	0.65
ATG5	associated_with	gene	0.65
ALZHEIMER'S DISEASE	treats	disease	0.65
CANCER	treats	disease	0.65
STROKE	treats	disease	0.65
ATG7	associated_with	gene	0.65
RAPAMYCIN	associated_with	drug	0.55
Stem Cell	inhibits	cell_type	0.50
oxidative stress	associated_with	phenotype	0.50
Autophagy	inhibits	process	0.50
ERK1	inhibits	gene	0.50
disease	regulates	disease	0.50
oxidative stress	inhibits	phenotype	0.50
Neurogenesis	activates	pathway	0.50
NATURAL COMPOUNDS	interacts_with	concept	0.50
ALZHEIMER'S DISEASE	activates	disease	0.50
Sod1	interacts_with	gene	0.50
Proteins	interacts_with	protein	0.50
CLDN5	interacts_with	gene	0.50
mitophagy	activates	pathway	0.50
oxidative stress	activates	phenotype	0.50
NF-κB	activates	concept	0.50
aging	associated_with	phenotype	0.50
Neurodegeneration	associated_with	disease	0.50
aging	activates	phenotype	0.50
Pi3K	activates	pathway	0.50
Autophagy	activates	process	0.50
mTOR	activates	entity	0.50
cancer	activates	disease	0.50
Nf-Kb	regulates	pathway	0.50
cancer	associated_with	disease	0.50
APOPTOSIS	activates	process	0.50
aplp1	interacts_with	gene	0.50
PI3K/AKT/mTOR	activates	pathway	0.50
TUMOR	associated_with	disease	0.50
TUMOR	regulates	disease	0.50
ferroptosis	regulates	phenotype	0.50
Gastric Cancer	associated_with	disease	0.50
MTOR SIGNALING	activates	pathway	0.50
CELL DEATH	activates	concept	0.50
LC3B	activates	protein	0.50
Pi3K	inhibits	pathway	0.50
mTOR	inhibits	entity	0.50
ferroptosis	inhibits	phenotype	0.50
apoptosis	activates	process	0.50
Gastric Cancer	activates	disease	0.50
Rheumatoid Arthritis	activates	disease	0.50
TGFB1	regulates	gene	0.50
TNFA	regulates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Why does Metformin fail to delay CJD progression despite improving anti-aging ha

neurodegeneration | 2026-04-14 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Both compounds similarly reduced aging hallmarks (AMPK, Nrf2, COX IV1) and infla

closed · Rounds: 4 · Score: 0.68 · 2026-04-16

Related Research

Hypotheses and analyses mentioning CURCUMIN in their description or question text

No additional research found