Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about abcd1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ABCD1 |
| Full Name | ATP Binding Cassette Subfamily D Member 1 (ALDP) |
| Chromosome | Xq28 |
| Protein Type | Transporter |
| Function | is a peroxisomal half-transporter that plays an essential role in the import and metabolism of very long-chain fatty acids (VLCFAs) [1]. |
| Primary Expression | Brain (oligodendrocytes, astrocytes), adrenal cortex, liver, kidney, peroxisomes |
| Molecular Weight | 80 kDa |
| Amino Acids | 745 aa |
| Exons | 10 |
| UniProt ID | P33897 |
| NCBI Gene ID | 215 |
| Ensembl ID | ENSG00000101986 |
| OMIM | 300100 |
| GeneCards | ABCD1 |
| Human Protein Atlas | ABCD1 |
| Associated Diseases | X-Linked Adrenoleukodystrophy, Zellweger Spectrum, Peroxisomal Biogenesis Disorders |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ABCD1["ABCD1"]
ABCD1 -->|"activates"| Als["Als"]
ABCD1 -->|"expressed in"| Inflammation["Inflammation"]
ABCD1 -->|"activates"| Neurodegeneration["Neurodegeneration"]
ABCD1 -->|"activates"| ABCD2["ABCD2"]
ABCD1 -->|"target for"| Proteasome["Proteasome"]
ABCD3["ABCD3"] -->|"activates"| ABCD1
CTNNB1["CTNNB1"] -->|"activates"| ABCD1
INFLAMMATION["INFLAMMATION"] -->|"activates"| ABCD1
OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| ABCD1
NR1H3["NR1H3"] -->|"activates"| ABCD1
ICAM1["ICAM1"] -->|"inhibits"| ABCD1| Target | Relation | Type | Str |
|---|---|---|---|
| Als | activates | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Inflammation | expressed_in | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| ABCD2 | activates | gene | 0.60 |
| ABCD2 | contributes_to | gene | 0.60 |
| ABCD2 | expressed_in | gene | 0.60 |
| ABCD2 | associated_with | gene | 0.60 |
| CLDN5 | inhibits | gene | 0.60 |
| MMP9 | activates | gene | 0.60 |
| MYC | activates | gene | 0.60 |
| SIRT1 | expressed_in | gene | 0.60 |
| Proteasome | therapeutic_target | pathway | 0.60 |
| INFLAMMATION | expressed_in | gene | 0.60 |
| Oxidative Stress | activates | pathway | 0.60 |
| Cholesterol | activates | pathway | 0.60 |
| Blood-Brain Barrier | activates | pathway | 0.60 |
| ATP | activates | gene | 0.60 |
| benchmark_ot_ad_answer_key:ABCD1 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ABCD3 | activates | gene | 0.60 |
| ABCD3 | contributes_to | gene | 0.60 |
| ABCD3 | expressed_in | gene | 0.60 |
| ABCD3 | associated_with | gene | 0.60 |
| CTNNB1 | activates | gene | 0.60 |
| ABCD2 | associated_with | gene | 0.60 |
| NR1H3 | activates | gene | 0.60 |
| ICAM1 | inhibits | gene | 0.60 |
| ABCD2 | expressed_in | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| OXIDATIVE STRESS | activates | gene | 0.60 |
| BLOOD-BRAIN BARRIER DYSFUNCTION | activates | gene | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
| benchmark_ot_ad_answer_key:ABCD1 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||