| Gene Symbol | CYLD |
| Chromosome | 16q12.1 |
| Protein Type | Protease |
| Function | CYLD is a ubiquitin-specific protease (USP) that specifically cleaves Lys63-linked polyubiquitin chains. |
| Primary Expression | Brain, Spinal Cord, Lymph Nodes, Skin |
| Pathways | NF-κB, Wnt, NF-κB signaling, Wnt signaling |
| UniProt ID | Q9NQC8 |
| NCBI Gene ID | 79583 |
| Ensembl ID | ENSG00000083799 |
| OMIM | 605018 |
| GeneCards | CYLD |
| Human Protein Atlas | CYLD |
| N-terminal CAP-Gly domain | Mediates interactions with microtubules and signaling complexes |
| B Box domain | Involved in protein-protein interactions |
| USP catalytic domain | The C-terminal protease domain containing the conserved Cys860 catalytic residue |
| Associated Diseases | ALS, Blood-Brain Barrier Dysfunction, Cancer, Infection, Inflammation |
| Interactions | APAF1, TXNIP, TBK1, ERK1, RIPK1, TRAF6 |
| KG Connections | 124 knowledge graph edges |
| Databases | GeneCardsHPASTRING |