| Gene Symbol | DNAJB6 |
| Aliases | MRJ, HLJ1, DNAJB6 |
| Chromosome | 7p12.3 |
| Protein Family | Hsp40/DnaJ family (subfamily B) |
| Protein Type | Chaperone |
| Target Class | Protein |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Mechanism of Action | Prioritized from 1 SciDEX hypotheses, including: HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor |
| Primary Expression | Broad, high in muscle and brain |
| Druggability | Low (0.50) |
| Clinical Stage | Phase I |
| Molecular Weight | ~38 kDa (isoform a), ~26 kDa (isoform b) |
| Amino Acids | 326 aa |
| Pathways | proteostasis |
| UniProt ID | O75186 |
| GeneCards | DNAJB6 |
| Human Protein Atlas | DNAJB6 |
| Associated Diseases | ALS, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Dementia |
| Known Drugs/Compounds | amyloid-beta 42 |
| Interactions | FUS, GAIN, HSP70, MYOT, NBR1, P62 |
| SciDEX Target | View Target Profile |
| SciDEX Hypotheses | HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding |
| KG Connections | 471 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |