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DNAJB6

DNAJB6 Protein

Score: 0.327 Price: $0.33 Undruggable Druggability Status: active Wiki: DNAJB6 Gene
HYPOTHESES
1
PAPERS
8
KG EDGES
0
DEBATES
1

3D Protein Structure

🧬 DNAJB6 — PDB 6U3R Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Druggability & Clinical Context

Druggability
Undruggable
Score: 0.23
Clinical Stage
Preclinical
Target Class
Protein
Safety
0.50
Druggability Analysis
Drug Development0.00
Structural Tractability0.30
Target Class0.50
Safety Profile0.50
Key Metrics
PDB Structures:
0
Known Drugs:
0
Approved:
0
In Clinical Trials:
0
Mechanism: Prioritized from 1 SciDEX hypotheses, including: HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
Known Drugs:
No known drugs targeting this protein
Structural Data:
PDB —AlphaFold ✓Cryo-EM —
UniProt: O75190

🧬 3D Protein Structure

🧬 DNAJB6 — PDB 6U3R Click to expand interactive 3D viewer

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

3D Protein Structure (AlphaFold)

Open full viewer

AlphaFold predicted structure available for O75190

View AlphaFold Structure

Linked Hypotheses (3)

J-protein substrate specificity codes enable HSP70 discrimination of β-sheet versus α-helical misfol0.840
HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor0.544
Distinct J-protein architectures decode exposed β-sheet recognition codes to enable selective pathog0.484

Linked Experiments (0)

No linked experiments

Scoring Dimensions

Portfolio 0.00 (25%) Druggability 0.23 (20%) Evidence 0.64 (20%) Safety 0.50 (15%) Competitive 0.80 (10%) Connectivity 0.00 (10%) 0.327 composite

Knowledge Graph (20)

activates (4)

DNAJB6→FUSDNAJB6→MYOTDNAJB6→NBR1DNAJB6→P62

associated with (2)

DNAJB6→Alzheimer's diseaseDNAJB6→LGMDD1

causes (1)

DNAJB6→Myofibrillar Myopathy

co discussed (5)

BRCA1→DNAJB6DES→DNAJB6DNAJB6→FLNCDNAJB6→STINGDNAJB6→UBIQUITIN

inhibits (3)

DNAJB6→amyloid-betaDNAJB6→GAINDNAJB6→HSP70

interacts with (1)

DNAJB6→hnRNPA2B1

involved in (1)

DNAJB6→proteostasis

modulates (1)

DNAJB6→FUS

references (2)

DNAJB6 Protein→DNAJB6HSP90 Protein (Heat Shock Protein 90)→DNAJB6

Debate History (1)

Should DNAJB6 (DNAJB6 Protein) be prioritized as a therapeutic target for neurod2026-04-26
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