protein 1,999 words KG: GBAPROTEIN 2026-03-23
kind:proteinsection:proteinsstate:publishedevidence:strong
Contents

Glucocerebrosidase (GCase)

🔬 Protein Info
Gene SymbolGBA
Full NameGlucocerebrosidase (GCase)
Protein TypeProtein
Functionis a critical gene in the intersection of lysosomal storage disorders and neurodegenerative diseases.
Molecular Weight60 kDa
Amino Acids536 aa
PathwaysAmyloid, Autophagy, Autophagy-Lysosomal Pathway, Chaperone, Epigenetic
UniProt IDSearch UniProt
Ensembl IDENSG00000177628
GeneCardsGBA
Human Protein AtlasGBA
Associated DiseasesAD, ALI, ALS, Aging, Alzheimer
InteractionsFUNDC1, AMBRA1, PINK1, BCL2L13, NLRP3, ABCD3
KG Connections1489 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (3)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (10)

Does TFEB activation directly restore mutant GBA enzyme acti
molecular biology · failed
What is the therapeutic window between GCS inhibition effica
neurodegeneration · failed
GBA-Synuclein Loop: Therapeutic Strategies for Parkinson's D
neurodegeneration · completed
GBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

Related Experiments (14)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in