| Gene Symbol | GRIN2B |
| Full Name | GRIN2B — NMDA Receptor Subunit 2B |
| Aliases | NMDA Receptor Subunit 2B |
| Chromosome | 12p13.1 |
| Protein Family | Ionotropic glutamate receptor (iGluR) family |
| Protein Type | Gene |
| Function | The GRIN2B subunit contributes to the unique pharmacological and biophysical properties of NMDA receptors |
| Primary Expression | Prefrontal Cortex, Cortex, Ventral Tegmental Area, Substantia Nigra |
| Subcellular Localization | Postsynaptic membrane, endoplasmic reticulum, Golgi |
| Molecular Weight | ~180 kDa (full-length); C-terminal tail ~70 kDa |
| Pathways | Circadian Rhythm, Calcium Signaling, Epigenetic, synaptic plasticity |
| UniProt ID | Q8VHX6 (mouse, ortholog) |
| GeneCards | GRIN2B |
| Human Protein Atlas | GRIN2B |
| Protein Name | Glutamate Ionotropic Receptor NMDA Type Subunit 2B (GluN2B/NR2B) |
| Associated Diseases | ALS, Alzheimer, Bipolar, Bipolar Disorder, Depression |
| Interactions | GRM3, GRM4, NCAM1, NRG1, RGS4, SYNGR1 |
| SciDEX Hypotheses | GluN2B-Mediated Thalamocortical Control of Glympha Thalamocortical Synchrony Restoration via NMDA Mod Cortico-Striatal Synchrony Restoration via NMDA Mo |
| KG Connections | 159 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |