concept

BIPOLAR DISORDER

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BIPOLAR DISORDER: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

70Connections

0Hypotheses

0Analyses

30Outgoing

11Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	BIPOLAR DISORDER
Key Genes/Proteins	DRD2, APP
Related Diseases	SCHIZOPHRENIA, NEURODEGENERATION, SEROTONIN, DEPRESSION

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    BIPOLAR_DISORDER["BIPOLAR DISORDER"]
    BIPOLAR_DISORDER -->|"interacts"| SCHIZOPHRENIA["SCHIZOPHRENIA"]
    BIPOLAR_DISORDER -->|"interacts"| DEPRESSION["DEPRESSION"]
    BIPOLAR_DISORDER -->|"interacts"| EPILEPSY["EPILEPSY"]
    BIPOLAR_DISORDER -->|"interacts"| GRIN2B["GRIN2B"]
    BIPOLAR_DISORDER -->|"regulates"| HYPOTHALAMUS["HYPOTHALAMUS"]
    BIPOLAR_DISORDER -->|"expressed in"| PREFRONTAL_CORTEX["PREFRONTAL CORTEX"]
    lithium["lithium"] -->|"treats"| BIPOLAR_DISORDER
    RELN["RELN"] -->|"implicated in"| BIPOLAR_DISORDER
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"interacts"| BIPOLAR_DISORDER
    ANGIOGENESIS["ANGIOGENESIS"] -->|"interacts"| BIPOLAR_DISORDER

Outgoing (41)

Target	Relation	Type	Str
SCHIZOPHRENIA	associated_with	disease	0.80
SCHIZOPHRENIA	interacts_with	disease	0.65
GRAY MATTER	destabilizes	brain_region	0.65
NEURODEGENERATION	activates	disease	0.65
DEPRESSION	associated_with	disease	0.50
SCHIZOPHRENIA	regulates	disease	0.50
LITHIUM	associated_with	drug	0.50
GRAY MATTER	associated_with	brain_region	0.50
DRD2	associated_with	gene	0.50
THALAMUS	associated_with	brain_region	0.50
MELATONIN	associated_with	drug	0.50
APP	associated_with	gene	0.50
KETAMINE	associated_with	drug	0.45
CORTEX	associated_with	brain_region	0.45
DEPRESSION	interacts_with	disease	0.35
EPILEPSY	interacts_with	disease	0.35
GRIN2B	interacts_with	gene	0.35
HYPOTHALAMUS	regulates	brain_region	0.35
DEPRESSION	regulates	disease	0.35
PREFRONTAL CORTEX	expressed_in	brain_region	0.35
SCHIZOPHRENIA	expressed_in	disease	0.35
DEPRESSION	expressed_in	disease	0.35
CHRNA7	expressed_in	gene	0.35
CHRNA7	associated_with	gene	0.35
NEUROINFLAMMATION	interacts_with	process	0.35
MACROPHAGES	interacts_with	cell_type	0.35
INFLAMMATION	regulates	process	0.35
PARKINSON'S DISEASE	associated_with	disease	0.35
INFLAMMATION	associated_with	process	0.35
CANCER	associated_with	disease	0.35

Incoming (29)

Source	Relation	Type	Str
RELN	implicated_in	entity	0.85
SEROTONIN	regulates	phenotype	0.65
MELATONIN	activates	drug	0.60
ANXIETY	associated_with	disease	0.50
PREFRONTAL CORTEX	associated_with	brain_region	0.45
ALZHEIMER'S DISEASE	interacts_with	disease	0.35
ALZHEIMER'S DISEASE	regulates	disease	0.35
ANGIOGENESIS	interacts_with	process	0.35
ANGIOGENESIS	regulates	process	0.35
ANGIOGENESIS	associated_with	process	0.35
ALZHEIMER'S DISEASE	associated_with	disease	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

BIPOLAR DISORDER

Understanding Entity Pages

Wiki Pages (20)

Frontotemporal Dementia (FTD)

CNTN5 — Contactin 5

Mitophagy Pathway in Neurodegeneration

Lithium for PSP/CBS — Phase 2 Trial

lithium-tauopathy

MACF1 — Microtubule-actin crosslinking factor 1

mitophagy-defect

Multiple Sclerosis (MS)

Allen Human Brain Atlas

Autophagy Failure Comparison -- AD/PD/ALS/FTD/HD

KarXT+EC Phase 3 (NCT07011732): Enhanced Formulation for AD Agitation

A 52-Week, Open-Label Extension Study of ACP-204 in Adults With Alzheimer's D... (NCT06194799)

WNT4 Gene

Sleep Architecture Changes in CBS and PSP

CORT108297 Phase 2 (NCT04601038) - Stress Attenuation in AD

Japanese Neurodegeneration Biotech Companies

Calcium Dysregulation to Excitotoxicity Pathway

NIH Drug Repurposing Program for Neurodegenerative Diseases