gene

FYN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FYN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

452Connections

2Hypotheses

5Analyses

50Outgoing

50Incoming

0Experiments

5Debates

Summary

Page for FYN — FYN Proto-Oncogene, Src Family Tyrosine Kinase

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🧬 Gene Info

Gene Symbol	FYN
Full Name	FYN Proto-Oncogene, Src Family Tyrosine Kinase
Aliases	Fyn Tyrosine Kinase
Chromosome	6q21.
Protein Type	Receptor
Function	encodes a member of the Src family of non-receptor tyrosine kinases (SFKs).
Primary Expression	T-cells, NK cells, and other immune cells
Molecular Weight	60 kDa
Amino Acids	537 aa
Pathways	Akt, Apoptosis, Dendritic Spine, Endocytosis, Pi3K
UniProt ID	P39687
NCBI Gene ID	2534
Ensembl ID	ENSG00000110881
OMIM	137025
GeneCards	FYN
Human Protein Atlas	FYN
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease
Interactions	Actin, AD, ADRB2, AKT, ALZHEIMER, ALZHEIMER'S DISEASE
SciDEX Hypotheses	FYN-Mediated Extracellular Vesicle Release Inhibit
KG Connections	443 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FYN — AlphaFold P39687 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

FYN — FYN Proto-Oncogene, Src Family Tyrosine Kinase

gene · 725 words

→

FYN Protein (Fyn Tyrosine Kinase)

protein · 1173 words

→

Pathway Diagram

graph TD
    FYN["FYN"]
    FYN -->|"activates"| STAT3["STAT3"]
    FYN -->|"upregulates"| IL12A["IL12A"]
    FYN -->|"regulates"| Kv1_3["Kv1.3"]
    FYN -->|"causes"| dopaminergic_neuron["dopaminergic neuron"]
    FYN -->|"activates"| neuroinflammation["neuroinflammation"]
    FYN -->|"activates"| microglia_activation["microglia activation"]
    FYN -->|"regulates"| Schizophrenia["Schizophrenia"]
    FYN -->|"regulates"| Epilepsy["Epilepsy"]
    FYN -->|"regulates"| Alzheimer["Alzheimer"]
    FYN -->|"regulates"| Autism["Autism"]
    JUN["JUN"] -->|"regulates"| FYN
    LCK["LCK"] -->|"activates"| FYN
    PKC["PKC"] -->|"activates"| FYN
    SRC["SRC"] -->|"activates"| FYN
    PI3K["PI3K"] -->|"regulates"| FYN
    GENES["GENES"] -->|"activates"| FYN
    NRF2["NRF2"] -->|"activates"| FYN
    CD36["CD36"] -->|"inhibits"| FYN
    AKT["AKT"] -->|"regulates"| FYN
    BACH1["BACH1"] -->|"activates"| FYN

Outgoing (330)

Target	Relation	Type	Str
Dopaminergic Neuron Loss	causes	phenotype	0.95
STAT3	activates	gene	0.95
tau phosphorylation at Tyr18	activates	process	0.90
synaptic function	regulates	process	0.90
dendritic spines	localizes_to	brain_region	0.90
synaptic dysfunction	causes	phenotype	0.90
LTP and NMDA receptor signaling	essential_for	process	0.90
Mitochondrial Aggregation	causes	phenotype	0.90
SYNAPTIC_FUNCTION	associated_with	phenotype	0.90
Microglia Activation	causes	phenotype	0.90
RELN	interacts_with	entity	0.90
Parkinson'S Disease	risk_factor_for	disease	0.90
KV1.3	upregulates	gene	0.85
KCNA3	modulates	gene	0.85
Parkinson's Disease	risk_factor_for	disease	0.85
KV1.3	modulates	gene	0.85
NFE2L2	phosphorylates	protein	0.85
ALZHEIMER'S DISEASE	associated_with	disease	0.85
NEURONAL MIGRATION	involved_in	entity	0.85
PARKINSON'S DISEASE	associated_with	disease	0.85
IL12A	upregulates	gene	0.80
KV1.3	phosphorylates	protein	0.80
Alzheimer	associated_with	disease	0.75
Aging	expressed_in	disease	0.75
Parkinson	associated_with	disease	0.75
TREM2	associated_with	gene	0.70
TAU	associated_with	gene	0.70
NMDA receptor	regulates	protein	0.70
NMDAR excitotoxic signaling	regulates	pathway	0.70
Alzheimer's disease	associated_with	disease	0.70
dopaminergic neuron	causes	cell_type	0.70
NMDAR signaling	modulates	pathway	0.70
ALZHEIMER	associated_with	gene	0.70
neuroinflammation	activates	process	0.70
Kv1.3	regulates	protein	0.70
MICROGLIA	activates	gene	0.70
PARKINSON	associated_with	gene	0.70
Parkinson's disease	associated_with	disease	0.70
Apoptosis	activates	pathway	0.70
GRIN2B	phosphorylates	gene	0.70
neuron projection development	regulates	process	0.70
microglia activation	activates	process	0.70
cell projection organization	regulates	process	0.70
memory formation	regulates	phenotype	0.70
tau protein	regulates	protein	0.70
PTEN	acts_upstream_of	protein	0.70
PTEN-PI3K signaling	associated_with	pathway	0.70
MAPT	regulates	gene	0.70
Neuroinflammation	inhibits	disease	0.65
UBIQUITIN	ubiquitinates	gene	0.65

Incoming (122)

Source	Relation	Type	Str
PrP^Sc	activates	protein	0.90
AΒ	activates	gene	0.90
Apoer2	activates	protein	0.85
GSK3B	phosphorylates	gene	0.85
ABETA	activates	protein	0.80
CLU	expresses	gene	0.70
APP	associated_with	gene	0.70
APOE	expresses	gene	0.70
BIN1	interacts_with	gene	0.70
APOPTOSIS	activates	gene	0.70
Curcumin	inhibits	drug	0.70
DOPAMINERGIC	inhibits	cell_type	0.65
PKC	activates	gene	0.60
SRC	associated_with	gene	0.60
CAMK2A	associated_with	gene	0.60
COMT	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
SRC	activates	gene	0.60
PI3K	regulates	gene	0.60
NRF2	activates	gene	0.60
AKT	regulates	gene	0.60
BACH1	activates	gene	0.60
CUL3	regulates	gene	0.60
UBC	associated_with	gene	0.60
PI3K	phosphorylates	gene	0.60
CUL3	activates	gene	0.60
KEAP1	activates	gene	0.60
REELIN	associated_with	gene	0.60
AKT	activates	gene	0.60
BACH1	phosphorylates	entity	0.60
AKT	phosphorylates	entity	0.60
HOMER1	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
UBIQUITIN	activates	gene	0.60
AURKA	associated_with	gene	0.60
CASS4	associated_with	gene	0.60
GRN	inhibits	gene	0.60
PTK2B	inhibits	gene	0.60
APP	causes	gene	0.60
APOE	activates	gene	0.60
LRRK2	associated_with	gene	0.60
TAU	activates	gene	0.60
AKT1	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
BACH1	degrades	gene	0.60
NRF2	degrades	gene	0.60
AND	causes	gene	0.60
DAB1	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
LCK	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Fyn-anchored dendritic tau/NMDAR signaling persists after tr	0.670	neurodegeneration	Does tau dendritic missorting persist in
FYN-Mediated Extracellular Vesicle Release Inhibition	0.000	-	Tau propagation mechanisms and therapeut