protein 1,674 words KG: HDAC4PROTEIN 2026-03-29
kind:proteinsection:proteinsstate:publishedtopic:alzheimerstopic:parkinsonstopic:huntingtons
Contents

HDAC4 Protein

🔬 Protein Info
Gene SymbolHDAC4
Full NameHistone Deacetylase 4
AliasesHDAC4PROTEIN
Chromosome2q37.3
Protein FamilyHistone deacetylase, Class IIa
FunctionHistone Modification: Removes acetyl groups from lysine tails of histones H3 and H4
Subcellular Localization</strong></td><td>Nucleus/Cytoplasm (signal-dependent)</td></tr>
Molecular Weight119 kDa
Amino Acids1088 aa
PathwaysNF-κB, AMPK
UniProt ID[P56524](https://www.uniprot.org/uniprot/P56524)
Ensembl IDENSG00000113048
OMIM605314
GeneCardsHDAC4
Human Protein AtlasHDAC4
Associated DiseasesALS, Aging, Alzheimer, Soft Tissue Sarcoma, Tumor, dementia
InteractionsMEF2A, AQP1, TNF, CDK2, HUNTINGTIN, DNAJB6
KG Connections182 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56
HDAC3-Selective Inhibition for Clock Reset
Score: 0.46
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (6)

SAHA@LIPO-ANG2 therapeutic efficacy in 5xFAD mice
validation · proposed · Score: 0.90
HDAC4 inhibition and NHE6 expression mechanism study
exploratory · proposed · Score: 0.85
Neuroimmune modulation and Aβ clearance mechanisms
exploratory · proposed · Score: 0.82
Epigenetic Dysregulation in Huntington's Disease — Therapeut
validation · proposed · Score: 0.40
Epigenetic Regulation Dysfunction in Alzheimer's and Parkins
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in