protein 1,709 words KG: HDAC9PROTEIN 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

HDAC9 Protein

🔬 Protein Info
Gene SymbolHDAC9
Full NameHistone Deacetylase 9
Chromosome7p21.1
Protein FamilyClass IIa histone deacetylase family
Functionencodes a class IIa histone deacetylase that plays crucial roles in epigenetic regulation, transcriptional control, and cellular signaling in the brain.
Primary ExpressionBrain, heart, skeletal muscle
Subcellular LocalizationNucleus, cytoplasm (signal-dependent shuttling)
Molecular Weight~110 kDa (full-length isoform)
UniProt IDQ9UKV0
NCBI Gene ID9734
Ensembl IDENSG00000048828
OMIM606365
GeneCardsHDAC9
Human Protein AtlasHDAC9
Protein NameHDAC9 (Histone Deacetylase 9)
Associated DiseasesAls, Coronary Artery Disease, Inflammation, Stroke
InteractionsNRF2, KDR, POU5F1, INFLAMMATION, NANOG, HDAC5
KG Connections38 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (11)

Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56
HDAC3-Selective Inhibition for Clock Reset
Score: 0.46
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

Epigenetic Dysregulation in Huntington's Disease — Therapeut
validation · proposed · Score: 0.40
Epigenetic Regulation Dysfunction in Alzheimer's and Parkins
clinical · proposed · Score: 0.40
Microglial Contributions to Huntington's Disease Pathogenesi
validation · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in