protein 1,297 words KG: HLADRB1PROTEIN 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

HLA-DRB1 Protein

🔬 Protein Info
Gene SymbolHLA
Full NameDRB1 Protein
AliasesHLADRB1PROTEIN
Protein FamilyMHC Class II beta chain family
Primary ExpressionCa1, Cortex
Subcellular LocalizationEndosomal membrane, cell surface
Molecular Weight~30 kDa (mature protein)
PathwaysJak-Stat, Apoptosis, Necroptosis, Epigenetic, Immune Response
UniProt IDP01911
GeneCardsHLA
Human Protein AtlasHLA
Protein NameHLA-DRB1
GeneHLA-DRB1
Associated DiseasesALS, Aging, Alzheimer, Alzheimer's disease, Cardiovascular
InteractionsCANCER, P53, IL-23, AND, GENES, HSPA1A
KG Connections307 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (18)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (1)

Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in