| Gene Symbol | HTR2APROTEIN |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | ** | Plasma membrane, dendritic shafts, postsynaptic densities | |
| Molecular Weight | 60 kDa |
| GeneCards | HTR2APROTEIN |
| Human Protein Atlas | HTR2APROTEIN |
| Long C-terminal tail | Contains serine/threonine residues for phosphorylation and desensitization |
| Differential splicing | Generates multiple isoforms with distinct coupling properties |
| Palmitoylation sites | In the C-tail for membrane anchoring |
| Phospholipase C activation | Increases IP3 and DAG, raising intracellular calcium |
| Pyramidal neuron modulation | Excitatory effects in prefrontal cortex |
| Platelet aggregation | Peripheral 5-HT2A mediates platelet shape change |
| Smooth muscle contraction | Vascular and gastrointestinal effects |
| Dreaming and consciousness | HTR2A activity correlates with REM sleep |
| Associated Diseases | ALS, Alzheimer, Autism, Bipolar, Cancer |
| Interactions | HTR2C, SLC1A1, SLC6A2, CACNA1H, GABRB2, GRIA1 |
| KG Connections | 150 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |