Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CACNA1H: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | CACNA1H |
| Full Name | Calcium Voltage-Gated Channel Subunit Alpha1 H |
| Aliases | Cav3.2 T-type Calcium Channel |
| Chromosome | 16p13.3 |
| Function | The CACNA1H gene encodes the α1H subunit that forms the pore of the T-type calcium channel (CaV3.2). |
| UniProt ID | O43480 |
| NCBI Gene ID | 8916 |
| Ensembl ID | ENSG00000118260 |
| GeneCards | CACNA1H |
| Human Protein Atlas | CACNA1H |
| Disease | Association Type |
| Childhood Absence Epilepsy | Causative |
| Autism Spectrum Disorder | Risk Modulator |
| [Alzheimer's Disease](/diseases/alzheimers-disease) | Risk Modulator |
| Major Depression | Risk Modifier |
| Associated Diseases | Alzheimer, Autism, Bipolar, Cancer, Inflammation, Parkinson |
| Interactions | CACNA1I, CACNA2D1, CACNA2D2, DRD1, DRD2, GABRA1 |
| KG Connections | 112 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CACNA1H["<b>CACNA1H</b>"]
Alzheimer["Alzheimer"]
CACNA1H -->|"associated with"| Alzheimer
Cancer["Cancer"]
CACNA1H -->|"associated with"| Cancer
Schizophrenia["Schizophrenia"]
CACNA1H -->|"associated with"| Schizophrenia
Autism["Autism"]
CACNA1H -->|"associated with"| Autism
Parkinson["Parkinson"]
CACNA1H -->|"associated with"| Parkinson
Bipolar["Bipolar"]
CACNA1H -->|"associated with"| Bipolar
Inflammation["Inflammation"]
CACNA1H -->|"associated with"| Inflammation
CACNA1D["CACNA1D"]
CACNA1H -->|"associated with"| CACNA1D
CACNA1G["CACNA1G"]
CACNA1H -->|"associated with"| CACNA1G
HTR2C["HTR2C"]
CACNA1H -->|"associated with"| HTR2C
DRD2["DRD2"]
CACNA1H -->|"associated with"| DRD2
PARKINSON["PARKINSON"]
CACNA1H -->|"associated with"| PARKINSON
Dopaminergic["Dopaminergic"]
CACNA1H -->|"associated with"| Dopaminergic
CCS["CCS"]
CACNA1H -->|"contributes to"| CCS
CACNA2D2["CACNA2D2"]
CACNA1H -->|"associated with"| CACNA2D2
CACNA1C["CACNA1C"]
CACNA1H -->|"associated with"| CACNA1C
CACNA1I["CACNA1I"]
CACNA1H -->|"associated with"| CACNA1I
SLC1A1["SLC1A1"]
CACNA1H -->|"associated with"| SLC1A1
INFLAMMATION["INFLAMMATION"]
CACNA1H -->|"associated with"| INFLAMMATION
GABRA1["GABRA1"]
CACNA1H -->|"associated with"| GABRA1
AND["AND"]
CACNA1H -->|"associated with"| AND
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
CACNA1H -->|"associated with"| PARKINSON_S_DISEASE
CANCER["CANCER"]
CACNA1H -->|"associated with"| CANCER
GENES["GENES"]
CACNA1H -->|"associated with"| GENES
ALZHEIMER["ALZHEIMER"]
CACNA1H -->|"associated with"| ALZHEIMER
GRIA1["GRIA1"]
CACNA1H -->|"associated with"| GRIA1
SLC6A2["SLC6A2"]
CACNA1H -->|"associated with"| SLC6A2
CACNA1A["CACNA1A"]
CACNA1A -->|"associated with"| CACNA1H
CCS["CCS"]
CCS -->|"contributes to"| CACNA1H
CACNA1C["CACNA1C"]
CACNA1C -->|"associated with"| CACNA1H| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Schizophrenia | associated_with | disease | 0.65 |
| Autism | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Bipolar | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| CACNA1D | associated_with | gene | 0.60 |
| CACNA1G | associated_with | gene | 0.60 |
| HTR2C | associated_with | gene | 0.60 |
| DRD2 | associated_with | gene | 0.60 |
| CCS | contributes_to | gene | 0.60 |
| CACNA2D2 | associated_with | gene | 0.60 |
| CACNA1C | associated_with | gene | 0.60 |
| CACNA1I | associated_with | gene | 0.60 |
| SLC1A1 | associated_with | gene | 0.60 |
| GABRA1 | associated_with | gene | 0.60 |
| GRIA1 | associated_with | gene | 0.60 |
| SLC6A2 | associated_with | gene | 0.60 |
| CACNA1F | associated_with | gene | 0.60 |
| CACNA1E | associated_with | gene | 0.60 |
| CACNA2D1 | associated_with | gene | 0.60 |
| CACNA1A | associated_with | gene | 0.60 |
| DRD1 | associated_with | gene | 0.60 |
| GABRB2 | associated_with | gene | 0.60 |
| HTR2A | associated_with | gene | 0.60 |
| GRM5 | associated_with | gene | 0.60 |
| GRIK4 | associated_with | gene | 0.60 |
| CACNA1B | transports | gene | 0.60 |
| Rb | associated_with | protein | 0.60 |
| CACNA1I | interacts_with | gene | 0.60 |
| CACNA2D1 | interacts_with | gene | 0.60 |
| CACNA2D2 | interacts_with | gene | 0.60 |
| DRD1 | interacts_with | gene | 0.60 |
| DRD2 | interacts_with | gene | 0.60 |
| GABRA1 | interacts_with | gene | 0.60 |
| GRIK4 | interacts_with | gene | 0.60 |
| GRM5 | interacts_with | gene | 0.60 |
| HTR2A | interacts_with | gene | 0.60 |
| HTR2C | interacts_with | gene | 0.60 |
| SLC1A1 | interacts_with | gene | 0.60 |
| SLC6A2 | interacts_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| Dopaminergic | associated_with | cell_type | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CACNA1A | associated_with | gene | 0.60 |
| CCS | contributes_to | gene | 0.60 |
| CACNA1C | associated_with | gene | 0.60 |
| CACNA2D2 | associated_with | gene | 0.60 |
| CACNA1F | associated_with | gene | 0.60 |
| CACNA1I | associated_with | gene | 0.60 |
| CACNA2D1 | associated_with | gene | 0.60 |
| CACNA1E | associated_with | gene | 0.60 |
| GABRB2 | associated_with | gene | 0.60 |
| SLC1A1 | associated_with | gene | 0.60 |
| SLC6A2 | associated_with | gene | 0.60 |
| GRIK4 | associated_with | gene | 0.60 |
| GRIA1 | associated_with | gene | 0.60 |
| DRD1 | associated_with | gene | 0.60 |
| CACNA1B | associated_with | gene | 0.60 |
| GRM5 | associated_with | gene | 0.60 |
| HTR2A | associated_with | gene | 0.60 |
| GABRA1 | associated_with | gene | 0.60 |
| CACNA1G | associated_with | gene | 0.60 |
| GAIN | contributes_to | gene | 0.60 |
| CACNA1B | transports | gene | 0.60 |
| CACNA1A | interacts_with | gene | 0.60 |
| CACNA1C | interacts_with | gene | 0.60 |
| CACNA1F | interacts_with | gene | 0.60 |
| CACNA1G | interacts_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| CACNA1D | interacts_with | gene | 0.50 |
| CACNA2D2 | interacts_with | gene | 0.50 |
| CACNA1I | interacts_with | gene | 0.50 |
| CACNA2D1 | interacts_with | gene | 0.50 |
| CACNA1E | interacts_with | protein | 0.50 |
| DRD2 | interacts_with | gene | 0.50 |
| HTR2C | interacts_with | gene | 0.50 |
| DRD1 | interacts_with | gene | 0.50 |
| CACNA1B | interacts_with | gene | 0.50 |
| GABRA1 | interacts_with | gene | 0.50 |
| GRM5 | interacts_with | gene | 0.50 |
| GRIK4 | interacts_with | gene | 0.50 |
| SLC6A2 | interacts_with | gene | 0.50 |
| SLC1A1 | interacts_with | protein | 0.50 |
| HTR2A | interacts_with | protein | 0.50 |
| CACNA1E | co_expressed_with | protein | 0.50 |
| CACNA1G | co_expressed_with | protein | 0.50 |
| CACNA1B | co_expressed_with | gene | 0.50 |
| cacna1f | interacts_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||