protein

CACNA1H

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CACNA1H: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

112Connections
0Hypotheses
0Analyses
50Outgoing
47Incoming

Summary

Page for CACNA1H Protein (Cav3.2 T-type Calcium Channel)

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🔬 Protein Info
Gene SymbolCACNA1H
Full NameCalcium Voltage-Gated Channel Subunit Alpha1 H
AliasesCav3.2 T-type Calcium Channel
Chromosome16p13.3
FunctionThe CACNA1H gene encodes the α1H subunit that forms the pore of the T-type calcium channel (CaV3.2).
UniProt IDO43480
NCBI Gene ID8916
Ensembl IDENSG00000118260
GeneCardsCACNA1H
Human Protein AtlasCACNA1H
DiseaseAssociation Type
Childhood Absence EpilepsyCausative
Autism Spectrum DisorderRisk Modulator
[Alzheimer's Disease](/diseases/alzheimers-disease)Risk Modulator
Major DepressionRisk Modifier
Associated DiseasesAlzheimer, Autism, Bipolar, Cancer, Inflammation, Parkinson
InteractionsCACNA1I, CACNA2D1, CACNA2D2, DRD1, DRD2, GABRA1
KG Connections112 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: CACNA1H — AlphaFold O43480 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

CACNA1H Gene

gene · 855 words

Thalamic Reticular Nucleus in Epilepsy

cell · 1964 words

voltage-gated-calcium-channel-neurons

cell_type · 1814 words

Calcium Dysregulation Across Neurodegenerative Diseases

disease · 1687 words

Calcium Channel Dysfunction in Parkinson's Disease

mechanism · 1650 words

Dorsal Root Ganglion Neurons in Chronic Neuropathic Pain

cell · 1366 words

Pathway Diagram

graph TD
    CACNA1H["<b>CACNA1H</b>"]
    Alzheimer["Alzheimer"]
    CACNA1H -->|"associated with"| Alzheimer
    Cancer["Cancer"]
    CACNA1H -->|"associated with"| Cancer
    Schizophrenia["Schizophrenia"]
    CACNA1H -->|"associated with"| Schizophrenia
    Autism["Autism"]
    CACNA1H -->|"associated with"| Autism
    Parkinson["Parkinson"]
    CACNA1H -->|"associated with"| Parkinson
    Bipolar["Bipolar"]
    CACNA1H -->|"associated with"| Bipolar
    Inflammation["Inflammation"]
    CACNA1H -->|"associated with"| Inflammation
    CACNA1D["CACNA1D"]
    CACNA1H -->|"associated with"| CACNA1D
    CACNA1G["CACNA1G"]
    CACNA1H -->|"associated with"| CACNA1G
    HTR2C["HTR2C"]
    CACNA1H -->|"associated with"| HTR2C
    DRD2["DRD2"]
    CACNA1H -->|"associated with"| DRD2
    PARKINSON["PARKINSON"]
    CACNA1H -->|"associated with"| PARKINSON
    Dopaminergic["Dopaminergic"]
    CACNA1H -->|"associated with"| Dopaminergic
    CCS["CCS"]
    CACNA1H -->|"contributes to"| CCS
    CACNA2D2["CACNA2D2"]
    CACNA1H -->|"associated with"| CACNA2D2
    CACNA1C["CACNA1C"]
    CACNA1H -->|"associated with"| CACNA1C
    CACNA1I["CACNA1I"]
    CACNA1H -->|"associated with"| CACNA1I
    SLC1A1["SLC1A1"]
    CACNA1H -->|"associated with"| SLC1A1
    INFLAMMATION["INFLAMMATION"]
    CACNA1H -->|"associated with"| INFLAMMATION
    GABRA1["GABRA1"]
    CACNA1H -->|"associated with"| GABRA1
    AND["AND"]
    CACNA1H -->|"associated with"| AND
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    CACNA1H -->|"associated with"| PARKINSON_S_DISEASE
    CANCER["CANCER"]
    CACNA1H -->|"associated with"| CANCER
    GENES["GENES"]
    CACNA1H -->|"associated with"| GENES
    ALZHEIMER["ALZHEIMER"]
    CACNA1H -->|"associated with"| ALZHEIMER
    GRIA1["GRIA1"]
    CACNA1H -->|"associated with"| GRIA1
    SLC6A2["SLC6A2"]
    CACNA1H -->|"associated with"| SLC6A2
    CACNA1A["CACNA1A"]
    CACNA1A -->|"associated with"| CACNA1H
    CCS["CCS"]
    CCS -->|"contributes to"| CACNA1H
    CACNA1C["CACNA1C"]
    CACNA1C -->|"associated with"| CACNA1H

Outgoing (65)

TargetRelationTypeStr
Alzheimerassociated_withdisease0.65
Cancerassociated_withdisease0.65
Schizophreniaassociated_withdisease0.65
Autismassociated_withdisease0.65
Parkinsonassociated_withdisease0.65

Incoming (47)

SourceRelationTypeStr
CACNA1Aassociated_withgene0.60
CCScontributes_togene0.60
CACNA1Cassociated_withgene0.60
CACNA2D2associated_withgene0.60
CACNA1Fassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found