protein

GABRB2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABRB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

79Connections

0Hypotheses

0Analyses

50Outgoing

27Incoming

Summary

Page for GABRB2 Protein

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🔬 Protein Info

Gene Symbol	GABRB2
Full Name	GABRB2 (GABA-A Receptor Beta 2)
Aliases	GABA-A Receptor Beta 2
Chromosome	5q34
Function	GABRB2 encodes the beta 2 subunit of the GABA-A receptor, a ligand-gated chloride channel that mediates fast inhibitory neurotransmission in the central nervous system.
Molecular Weight	54 kDa
UniProt ID	[P47870](https://www.uniprot.org/uniprot/P47870)
Ensembl ID	ENSG00000145888
OMIM	137140
GeneCards	GABRB2
Human Protein Atlas	GABRB2
Channel function	GABA binding triggers Cl- influx, hyperpolarizing neurons
Synaptic localization	Primarily synaptic GABA-A receptors
Pharmacology	Target for benzodiazepines, barbiturates, and neurosteroids
Development	Critical for neuronal circuit formation
Associated Diseases	ALS, Alzheimer, Autism, Bipolar, Cancer, Inflammation
Interactions	GRIK4, GRM5, HTR2A, HTR2C, SLC1A1, SLC6A2
KG Connections	79 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (18)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GABRB2["<b>GABRB2</b>"]
    Alzheimer["Alzheimer"]
    GABRB2 -->|"associated with"| Alzheimer
    Cancer["Cancer"]
    GABRB2 -->|"associated with"| Cancer
    Schizophrenia["Schizophrenia"]
    GABRB2 -->|"associated with"| Schizophrenia
    Autism["Autism"]
    GABRB2 -->|"associated with"| Autism
    Parkinson["Parkinson"]
    GABRB2 -->|"associated with"| Parkinson
    Bipolar["Bipolar"]
    GABRB2 -->|"associated with"| Bipolar
    Inflammation["Inflammation"]
    GABRB2 -->|"associated with"| Inflammation
    SLC1A1["SLC1A1"]
    GABRB2 -->|"associated with"| SLC1A1
    SLC6A2["SLC6A2"]
    GABRB2 -->|"associated with"| SLC6A2
    GRIK4["GRIK4"]
    GABRB2 -->|"associated with"| GRIK4
    GRIA1["GRIA1"]
    GABRB2 -->|"associated with"| GRIA1
    DRD1["DRD1"]
    GABRB2 -->|"associated with"| DRD1
    CACNA1B["CACNA1B"]
    GABRB2 -->|"associated with"| CACNA1B
    GRM5["GRM5"]
    GABRB2 -->|"associated with"| GRM5
    ALZHEIMER["ALZHEIMER"]
    GABRB2 -->|"associated with"| ALZHEIMER
    HTR2A["HTR2A"]
    GABRB2 -->|"associated with"| HTR2A
    GABRA1["GABRA1"]
    GABRB2 -->|"associated with"| GABRA1
    CACNA1H["CACNA1H"]
    GABRB2 -->|"associated with"| CACNA1H
    HTR2C["HTR2C"]
    GABRB2 -->|"associated with"| HTR2C
    DRD2["DRD2"]
    GABRB2 -->|"associated with"| DRD2
    PARKINSON["PARKINSON"]
    GABRB2 -->|"associated with"| PARKINSON
    Dopaminergic["Dopaminergic"]
    GABRB2 -->|"associated with"| Dopaminergic
    INFLAMMATION["INFLAMMATION"]
    GABRB2 -->|"associated with"| INFLAMMATION
    AND["AND"]
    GABRB2 -->|"associated with"| AND
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    GABRB2 -->|"associated with"| PARKINSON_S_DISEASE
    CANCER["CANCER"]
    GABRB2 -->|"associated with"| CANCER
    GENES["GENES"]
    GABRB2 -->|"associated with"| GENES
    GRIK4["GRIK4"]
    GRIK4 -->|"associated with"| GABRB2
    CACNA1B["CACNA1B"]
    CACNA1B -->|"associated with"| GABRB2
    HTR2A["HTR2A"]
    HTR2A -->|"associated with"| GABRB2

Outgoing (52)

Target	Relation	Type	Str
Insomnia	therapeutic_target	disease	0.80
Alzheimer	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Schizophrenia	associated_with	disease	0.65
Autism	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Bipolar	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
SLC1A1	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
GRIK4	associated_with	gene	0.60
GRIA1	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
GRM5	associated_with	gene	0.60
HTR2A	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
CACNA1H	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
Rb	associated_with	protein	0.60
GRIK4	interacts_with	gene	0.60
GRM5	interacts_with	gene	0.60
HTR2A	interacts_with	gene	0.60
HTR2C	interacts_with	gene	0.60
SLC1A1	interacts_with	gene	0.60
SLC6A2	interacts_with	gene	0.60
HTR1A	targets	gene	0.60
MTNR1A	targets	gene	0.60
MTNR1B	targets	gene	0.60
GABRB3	phosphorylates	gene	0.60
NDUFV1	phosphorylates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
Dopaminergic	associated_with	cell_type	0.60
INFLAMMATION	associated_with	gene	0.60
AND	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
GENES	associated_with	gene	0.60
GABAergic neurons	expressed_in	cell_type	0.60
ALS	associated_with	disease	0.60
Hypothalamus	expressed_in	brain_region	0.55
Cerebellum	expressed_in	brain_region	0.55
Thalamus	expressed_in	brain_region	0.55
Cortex	expressed_in	brain_region	0.55
GRIA1	interacts_with	gene	0.50
GRIA1	co_expressed_with	gene	0.50
GRIK4	co_expressed_with	gene	0.50
HTR1A	co_expressed_with	gene	0.50

Incoming (27)

Source	Relation	Type	Str
GRIK4	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
HTR2A	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
CACNA1H	associated_with	gene	0.60
GRIA1	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
SLC1A1	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
GABRA1	targets	gene	0.60
ALZHEIMER	associated_with	gene	0.60
DRD2	interacts_with	gene	0.50
HTR2C	interacts_with	gene	0.50
DRD1	interacts_with	gene	0.50
CACNA1B	interacts_with	gene	0.50
GABRA1	interacts_with	gene	0.50
GRM5	interacts_with	gene	0.50
GRIK4	interacts_with	gene	0.50
SLC6A2	interacts_with	gene	0.50
SLC1A1	interacts_with	protein	0.50
HTR2A	interacts_with	protein	0.50
CACNA1H	interacts_with	protein	0.50
DRD2	co_expressed_with	gene	0.50
GABRA1	co_expressed_with	gene	0.50
CASP3	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GABRB2

Understanding Entity Pages

Summary

Wiki Pages (18)

GABRB2 — GABA-A Receptor Beta 2

GABRA2 Gene

GABRA4 Gene

GABRA6 Gene

GABRA3 Gene

GABRA5 Gene

GABRB3 Gene

Ventral Tegmental Area Gabaergic Neurons Expanded

GABRQ — GABA-A Receptor Theta Subunit

L23 Interneurons Schizophrenia

GABA-A Receptor Theta (GABRQ) Protein

GABRB3

GABA-A Alpha1 Neurons

GABRB2 Protein

GABA-A Receptor Beta2 Protein

NDUFV1 Gene