protein 1,789 words KG: IDEPROTEIN 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

Insulin-Degrading Enzyme (IDE)

🔬 Protein Info
Gene SymbolIDE
Full NameInsulin-Degrading Enzyme (IDE)
AliasesPage for IDE Gene
Chromosome10q23.33
Protein TypeProtease
FunctionPeptide hydrolysis, amyloid clearance
Subcellular LocalizationIDE is found in multiple cellular compartments:
Molecular Weight110 kDa
Amino Acids1019 aa
PathwaysOxidative Stress
UniProt IDSearch UniProt
NCBI Gene ID3416
GeneCardsIDE
Human Protein AtlasIDE
Associated DiseasesAls, Alzheimer, Alzheimer's disease, Diabetes, Insulin Resistance
Known Drugs/Compoundsmetformin
InteractionsCD36, PPAR, AKT, TAU, NEPRILYSIN, Rb
KG Connections205 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (19)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44
Brain Insulin Resistance with Glucose Transporter Dysfunctio
Score: 0.40

Related Analyses (13)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
APOE4 (Apolipoprotein E4)
disease · Pages share 4 hypotheses
APOE3 (Apolipoprotein E3)
disease · Pages share 4 hypotheses
APOE2 (Apolipoprotein E2)
disease · Pages share 4 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 4 hypotheses