protein 762 words KG: IDH1PROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

IDH1 Protein - Isocitrate Dehydrogenase 1

🔬 Protein Info
Gene SymbolIDH1
Full NameIsocitrate Dehydrogenase 1 (NADP+)
AliasesPage for IDH1 Gene, Page for IDH1 Protein
Chromosome2q33.3
Protein TypeEnzyme
FunctionIDH1 is a NADP+-dependent enzyme localized primarily in the cytosol and peroxisomes.
Subcellular LocalizationCytosol, Peroxisomes
Molecular Weight~47 kDa (per subunit)
PathwaysEpigenetic
UniProt IDO75874
NCBI Gene ID3417
Ensembl IDENSG00000138449
GeneCardsIDH1
Human Protein AtlasIDH1
GeneIDH1
Associated DiseasesAD, ADH, ALI, AMI, ARM, Aging
InteractionsMTOR, IDH2, VHL, MDM4, MCL1, VEGFA
KG Connections388 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.38
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (14)

IDH1 and IDH2 mutation sequencing in CNS and non-CNS tumors
exploratory · proposed · Score: 0.95
Clinical outcome analysis based on IDH mutation status
clinical · proposed · Score: 0.85
Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in