Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ADH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | ADH |
| Key Genes/Proteins | LDLR, APOB, PCSK9, RAB7A, LRP2, ACTB |
| Linked Hypotheses | 1 hypotheses |
Knowledge base pages for this entity
graph TD
ADH["ADH"]
LDLR["LDLR"] -->|"causes"| ADH
APOB["APOB"] -->|"causes"| ADH
PCSK9["PCSK9"] -->|"causes"| ADH
RAB7A["RAB7A"] -->|"implicated in"| ADH
LRP2["LRP2"] -->|"implicated in"| ADH
ACTB["ACTB"] -->|"implicated in"| ADH
CTSD["CTSD"] -->|"implicated in"| ADH
ATG["ATG"] -->|"implicated in"| ADH| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| LDLR | causes | gene | 0.72 |
| APOB | causes | gene | 0.72 |
| PCSK9 | causes | gene | 0.72 |
| RAB7A | implicated_in | gene | 0.50 |
| LRP2 | implicated_in | gene | 0.50 |
| ACTB | implicated_in | gene | 0.50 |
| CTSD | implicated_in | gene | 0.50 |
| ATG | implicated_in | gene | 0.50 |
| EGFR | implicated_in | gene | 0.50 |
| SREBF1 | implicated_in | gene | 0.50 |
| NADH | implicated_in | gene | 0.50 |
| MTORC1 | implicated_in | gene | 0.50 |
| PPARG | implicated_in | gene | 0.50 |
| RPS6KB1 | implicated_in | gene | 0.50 |
| PPARA | implicated_in | gene | 0.50 |
| LAMP1 | implicated_in | gene | 0.50 |
| RUBCN | implicated_in | gene | 0.50 |
| MTOR | implicated_in | gene | 0.50 |
| RAS | implicated_in | gene | 0.50 |
| RPS6 | implicated_in | gene | 0.50 |
| PIK3C3 | implicated_in | gene | 0.50 |
| ATP | implicated_in | gene | 0.50 |
| SQSTM1 | implicated_in | gene | 0.50 |
| CAT | implicated_in | gene | 0.50 |
| LIS1 | implicated_in | gene | 0.50 |
| DCX | implicated_in | gene | 0.50 |
| IDH2 | implicated_in | gene | 0.50 |
| NAD | implicated_in | gene | 0.50 |
| IDH1 | implicated_in | gene | 0.50 |
| HSPG2 | implicated_in | gene | 0.50 |
| AKT | implicated_in | gene | 0.50 |
| NTN1 | implicated_in | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Trans-Synaptic Adhesion Molecule Modulation | 0.340 | Alzheimer's Disease | Tau propagation mechanisms and therapeut |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| NRXN3-NLGN1 complex influences the development of depression induced by maternal [PMID:40286836] | Rong Y, Yan W, Gao Z, Yang Y, Xu C, Zhan | Brain research | 2025 | 0 |
| Membrane trafficking of synaptic adhesion molecules. [PMID:39322997] | ["Bogaciu C", "Rizzoli S"] | The Journal of physiology | 2025 | 0 |
| Activation of hypothalamic-pontine-spinal pathway promotes locomotor initiation [PMID:41353490] | ["Ji C", "Zhang Y", "Lin Z", "Zhao Z", " | Nature communications | 2025 | 0 |
| Molecular Signatures of Resilience to Alzheimer's Disease in Neocortical Layer 4 [PMID:39574639] | Dharshini SAP, Sanz-Ros J, Pan J, Tang W | bioRxiv : the preprint server | 2024 | 0 |
| Cross-disorder and disease-specific pathways in dementia revealed by single-cell [PMID:39265576] | Rexach JE, Cheng Y, Chen L, Polioudakis | Cell | 2024 | 0 |
| Organizing the synaptic junctions. [PMID:37060998] | ["Zhou Q"] | The Journal of biological chem | 2023 | 0 |
| A Neuroligin-1 mutation associated with Alzheimer's disease produces memory and [PMID:37260747] | Arias-Aragón F, Tristán-Clavijo E, Martí | iScience | 2023 | 0 |
| Reelin through the years: From brain development to inflammation. [PMID:37339050] | Alexander A, Herz J, Calvier L | Cell reports | 2023 | 0 |
| Molecular mechanisms of synaptogenesis. [PMID:36176941] | ["Qi C", "Luo L", "Feng I", "Ma S"] | Frontiers in synaptic neurosci | 2022 | 0 |
| In vivo nanoscopic landscape of neurexin ligands underlying anterograde synapse [PMID:36007521] | Nozawa K, Sogabe T, Hayashi A, Motohashi | Neuron | 2022 | 0 |
| Neuroligin-1 in brain and CSF of neurodegenerative disorders: investigation for [PMID:33522967] | Camporesi E, Lashley T, Gobom J, Lantero | Acta neuropathologica communic | 2021 | 0 |
| PSD-95 binding dynamically regulates NLGN1 trafficking and function. [PMID:31138690] | Jeong J, Pandey S, Li Y, Badger JD, Lu W | Proceedings of the National Ac | 2019 | 0 |
| NLGN1 and NLGN2 in the prefrontal cortex: their role in memory consolidation and [PMID:29278843] | Katzman A, Alberini CM | Current opinion in neurobiolog | 2018 | 0 |
| Declining levels of functionally specialized synaptic proteins in plasma neurona [PMID:29025866] | Goetzl EJ, Abner EL, Jicha GA, Kapogiann | FASEB journal : official publi | 2018 | 0 |
| Structural Insights into Modulation of Neurexin-Neuroligin Trans-synaptic Adhesi [PMID:28641111] | ["Kim J", "Kim D", "Won S", "Han K", "Pa | Neuron | 2017 | 0 |
| Role of Neurexin-1β and Neuroligin-1 in Cognitive Dysfunction After Subarachnoid [PMID:26219651] | ["Shen H", "Chen Z", "Wang Y", "Gao A", | Stroke | 2015 | 0 |
| Evidence for Association of Cell Adhesion Molecules Pathway and NLGN1 Polymorphi [PMID:26674772] | Zhang Z, Yu H, Jiang S, Liao J, Lu T, Wa | PloS one | 2015 | 0 |
| Neurexins. [PMID:24083347] | ["Reissner C", "Runkel F", "Missler M"] | Genome biology | 2013 | 0 |
| Genetic study of neurexin and neuroligin genes in Alzheimer's disease. [PMID:23403532] | Martinez-Mir A, González-Pérez A, Gayán | Journal of Alzheimer's disease | 2013 | 0 |
| Overexpression of the cell adhesion protein neuroligin-1 induces learning defici [PMID:19437420] | ["Dahlhaus R", "Hines R", "Eadie B", "Ka | Hippocampus | 2010 | 0 |