| Gene Symbol | LCKPROTEIN |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | T-lymphocytes where it is essential for T-cell receptor (TCR) signaling and T-cell development |
| Subcellular Localization | ** | Plasma membrane, Cytoplasm | |
| Molecular Weight | 57 kDa |
| GeneCards | LCKPROTEIN |
| Human Protein Atlas | LCKPROTEIN |
| Receptor signaling | Activated by growth factor receptors, integrin receptors, and immune receptors |
| Synaptic function | Phosphorylates NMDA receptor subunits, PSD-95, and other synaptic proteins |
| Cellular processes | Regulates cell proliferation, differentiation, survival, migration, and cytoskeletal organization |
| Alzheimer's Disease | Altered phosphorylation of tau and amyloid precursor protein processing |
| Parkinson's Disease | Involved in dopaminergic neuron signaling and survival |
| Cancer | Constitutively active in various cancers |
| Multi-kinase inhibitors | Dasatinib, bosutinib, saracatinib |
| Associated Diseases | Aging, Als, Alzheimer |
| Interactions | ACTB, APOPTOSIS, AUTOPHAGY, CAT, CCL5, CD19 |
| KG Connections | 65 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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