protein 1,093 words KG: LRP2PROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

LRP2 Protein - Megalin

🔬 Protein Info
Gene SymbolLRP2
Full NameLRP2 (Megalin)
AliasesPage for LRP2 Protein, Megalin
Chromosome2q31.1
Protein TypeProtein
Functionis a giant multiligand endocytic receptor of the LDL receptor family with high physiological relevance at epithelial interfaces, including the choroid plexus and brain barriers.
Molecular Weight600 kDa
Amino Acids630 aa
Exons79
PathwaysAngiogenesis, Apoptosis, Autophagy, Lipid Metabolism, Mtor
UniProt IDSearch UniProt
GeneCardsLRP2
Human Protein AtlasLRP2
Associated DiseasesAD, ADH, ALS, AMI, Aging
Known Drugs/Compoundsrapamycin
InteractionsEIF4EBP1, LAMP1, MCOLN1, SOX9, TFEB, ULK1
KG Connections267 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (12)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (7)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
APOE4 (Apolipoprotein E4)
disease · Pages share 4 hypotheses
APOE3 (Apolipoprotein E3)
disease · Pages share 4 hypotheses
APOE2 (Apolipoprotein E2)
disease · Pages share 4 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 4 hypotheses