| Gene Symbol | MBP |
| Full Name | Myelin Basic Protein |
| Aliases | MBPPROTEIN |
| Chromosome | 18q23 |
| Protein Family | MBP family (intrinsically disordered proteins) |
| Function | Membrane compaction: MBP interacts with the cytoplasmic surface of the oligodendrocyte membrane, facilitating the tight apposition of myelin lamellae [6] |
| Primary Expression | a developmentally regulated manner, with different isoforms predominant at different stages of oligodendrocyte maturation and myelination |
| Subcellular Localization | Cytoplasm, myelin sheath (plasma membrane) |
| Molecular Weight | 14-21.5 kDa (multiple isoforms) |
| Amino Acids | 197 aa |
| Exons | 11 |
| Pathways | MAPK |
| UniProt ID | P02686 |
| Ensembl ID | ENSG00000197971 |
| GeneCards | MBP |
| Human Protein Atlas | MBP |
| Associated Diseases | ALS, Alzheimer, Ms, Parkinson, dementia |
| Known Drugs/Compounds | metformin |
| Interactions | PLP1, MANF, GAP43, ELAVL3, GFAP, ATF3 |
| KG Connections | 377 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |