protein 1,671 words KG: NEFLPROTEIN 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

Neurofilament Light Chain Protein

🔬 Protein Info
Gene SymbolNEFLPROTEIN
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization| Neuronal axon (cytoskeleton) |- \! Protein Family | Type IV intermediate filam
Amino Acids543 aa
GeneCardsNEFLPROTEIN
Human Protein AtlasNEFLPROTEIN
Associated DiseasesAlzheimers_disease
InteractionsSTMN2, PVALB, RANK, CNR1, STATHMIN, NRGN
KG Connections200 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Multi-Modal Stress Response Harmonization
Score: 0.60
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59

Related Analyses (24)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

Related Experiments (17)

ALS Progression Rate Heterogeneity — mechanism and biomarker
clinical · proposed · Score: 0.40
Why Does Amyloid Removal Only Slow Decline 27%? — Mechanisti
clinical · proposed · Score: 0.40
Anti-Tau Immunotherapy Dosing Optimization
clinical · proposed · Score: 0.40
Axonal Transport Dysfunction Validation in Parkinson's Disea
clinical · proposed · Score: 0.40
Blood-Based Biomarker Panel for Early AD Detection
clinical · proposed · Score: 0.40

See Also (15)

Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 68 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 68 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 68 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 68 hypotheses
Vagus Nerve Pathway in Neurodegeneration
mechanism · Pages share 68 hypotheses