protein

CNR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CNR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

230Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

CNR1 is a protein involved in neurodegeneration research. Key relationships include: therapeutic target, causes, regulates. Associated with Als, Amyotrophic Lateral Sclerosis, Dementia. Connected to 48 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolCNR1
Full NameCannabinoid Receptor 1
Chromosome6q25.2
FunctionThe CNR1 gene encodes the cannabinoid receptor type 1 (CB1), a G protein-coupled receptor that is the most abundant cannabinoid receptor in the brain.
Molecular Weight53 kDa
PathwaysMAPK pathway
UniProt IDP21554
NCBI Gene ID1268
Ensembl IDENSG00000118432
OMIM114010
GeneCardsCNR1
Human Protein AtlasCNR1
Associated DiseasesALS, Amyotrophic Lateral Sclerosis, Depression, Neurodegeneration
Known Drugs/Compoundscannabinoids
InteractionsPPARG, PPAR, DRD1, MC4R, NLRP3, GRIK1
KG Connections230 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: CNR1 — AlphaFold P21554 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

CNR1 Gene

gene · 648 words

Endocannabinoid System Dysfunction Hypothesis in Parkinson's Disease

hypothesis · 3520 words

Endocannabinoid System in Neurodegeneration

mechanism · 2218 words

Nucleus Accumbens Shell Median Neurons

cell · 2086 words

Cholecystokinin-Expressing Interneurons (CCK Interneurons)

cell · 2022 words

Cannabinoid Receptor Neurons

cell_type · 1847 words

Pathway Diagram

graph TD
    CNR1["<b>CNR1</b>"]
    Cannabinoid_CB_1__Receptor_Evoked_Signal(["Cannabinoid CB(1) Receptor-Evoked Signalling"])
    CNR1 -->|"mediates"| Cannabinoid_CB_1__Receptor_Evoked_Signal
    Dementia{"Dementia"}
    CNR1 -->|"regulates"| Dementia
    Inflammation{"Inflammation"}
    CNR1 -->|"regulates"| Inflammation
    Ms{"Ms"}
    CNR1 -->|"regulates"| Ms
    CTSD["CTSD"]
    CNR1 -->|"therapeutic target"| CTSD
    NME1["NME1"]
    CNR1 -->|"therapeutic target"| NME1
    CACNA1E["CACNA1E"]
    CNR1 -->|"therapeutic target"| CACNA1E
    CACNA2D3["CACNA2D3"]
    CNR1 -->|"therapeutic target"| CACNA2D3
    PRKAB1["PRKAB1"]
    CNR1 -->|"therapeutic target"| PRKAB1
    DIABETIC_RETINOPATHY["DIABETIC RETINOPATHY"]
    CNR1 -->|"therapeutic target"| DIABETIC_RETINOPATHY
    EPAS1["EPAS1"]
    CNR1 -->|"therapeutic target"| EPAS1
    CEBPA["CEBPA"]
    CNR1 -->|"therapeutic target"| CEBPA
    GAP43["GAP43"]
    GAP43 -->|"interacts with"| CNR1
    GAP43 -->|"modulates"| CNR1
    EPAS1 -->|"therapeutic target"| CNR1
    CACNG6["CACNG6"]
    CACNG6 -->|"therapeutic target"| CNR1
    BIN1["BIN1"]
    BIN1 -->|"therapeutic target"| CNR1
    CHRNA2["CHRNA2"]
    CHRNA2 -->|"therapeutic target"| CNR1
    CEBPA -->|"therapeutic target"| CNR1
    GENES["GENES"]
    GENES -->|"therapeutic target"| CNR1
    NME1 -->|"therapeutic target"| CNR1
    PRKAB1 -->|"therapeutic target"| CNR1
    CACNA1E -->|"therapeutic target"| CNR1
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"regulates"| CNR1
    style CNR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (149)

TargetRelationTypeStr
synaptic transmissionregulatesprocess0.90
presynaptic terminalexpressed_incell_type0.90
neuronal signalingmediatespathway0.90
metabotropic signalinginvolved_inprocess0.85
MAPK signalingparticipates_inpathway0.70

Incoming (81)

SourceRelationTypeStr
cannabinoidsbindscompound0.95
EPAS1therapeutic_targetgene0.60
CACNG6therapeutic_targetgene0.60
BIN1therapeutic_targetgene0.60
CHRNA2therapeutic_targetgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found