Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CNR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CNR1 is a protein involved in neurodegeneration research. Key relationships include: therapeutic target, causes, regulates. Associated with Als, Amyotrophic Lateral Sclerosis, Dementia. Connected to 48 entities in the SciDEX knowledge graph.
| Gene Symbol | CNR1 |
| Full Name | Cannabinoid Receptor 1 |
| Chromosome | 6q25.2 |
| Function | The CNR1 gene encodes the cannabinoid receptor type 1 (CB1), a G protein-coupled receptor that is the most abundant cannabinoid receptor in the brain. |
| Molecular Weight | 53 kDa |
| Pathways | MAPK pathway |
| UniProt ID | P21554 |
| NCBI Gene ID | 1268 |
| Ensembl ID | ENSG00000118432 |
| OMIM | 114010 |
| GeneCards | CNR1 |
| Human Protein Atlas | CNR1 |
| Associated Diseases | ALS, Amyotrophic Lateral Sclerosis, Depression, Neurodegeneration |
| Known Drugs/Compounds | cannabinoids |
| Interactions | PPARG, PPAR, DRD1, MC4R, NLRP3, GRIK1 |
| KG Connections | 230 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CNR1["<b>CNR1</b>"]
Cannabinoid_CB_1__Receptor_Evoked_Signal(["Cannabinoid CB(1) Receptor-Evoked Signalling"])
CNR1 -->|"mediates"| Cannabinoid_CB_1__Receptor_Evoked_Signal
Dementia{"Dementia"}
CNR1 -->|"regulates"| Dementia
Inflammation{"Inflammation"}
CNR1 -->|"regulates"| Inflammation
Ms{"Ms"}
CNR1 -->|"regulates"| Ms
CTSD["CTSD"]
CNR1 -->|"therapeutic target"| CTSD
NME1["NME1"]
CNR1 -->|"therapeutic target"| NME1
CACNA1E["CACNA1E"]
CNR1 -->|"therapeutic target"| CACNA1E
CACNA2D3["CACNA2D3"]
CNR1 -->|"therapeutic target"| CACNA2D3
PRKAB1["PRKAB1"]
CNR1 -->|"therapeutic target"| PRKAB1
DIABETIC_RETINOPATHY["DIABETIC RETINOPATHY"]
CNR1 -->|"therapeutic target"| DIABETIC_RETINOPATHY
EPAS1["EPAS1"]
CNR1 -->|"therapeutic target"| EPAS1
CEBPA["CEBPA"]
CNR1 -->|"therapeutic target"| CEBPA
GAP43["GAP43"]
GAP43 -->|"interacts with"| CNR1
GAP43 -->|"modulates"| CNR1
EPAS1 -->|"therapeutic target"| CNR1
CACNG6["CACNG6"]
CACNG6 -->|"therapeutic target"| CNR1
BIN1["BIN1"]
BIN1 -->|"therapeutic target"| CNR1
CHRNA2["CHRNA2"]
CHRNA2 -->|"therapeutic target"| CNR1
CEBPA -->|"therapeutic target"| CNR1
GENES["GENES"]
GENES -->|"therapeutic target"| CNR1
NME1 -->|"therapeutic target"| CNR1
PRKAB1 -->|"therapeutic target"| CNR1
CACNA1E -->|"therapeutic target"| CNR1
INFLAMMATION["INFLAMMATION"]
INFLAMMATION -->|"regulates"| CNR1
style CNR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| synaptic transmission | regulates | process | 0.90 |
| presynaptic terminal | expressed_in | cell_type | 0.90 |
| neuronal signaling | mediates | pathway | 0.90 |
| metabotropic signaling | involved_in | process | 0.85 |
| MAPK signaling | participates_in | pathway | 0.70 |
| Dementia | regulates | disease | 0.65 |
| Inflammation | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | causes | disease | 0.65 |
| Als | causes | disease | 0.65 |
| Neurodegeneration | causes | disease | 0.65 |
| Neurodegeneration | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | regulates | disease | 0.65 |
| Depression | interacts_with | disease | 0.65 |
| Epilepsy | interacts_with | disease | 0.65 |
| Alzheimer | interacts_with | disease | 0.65 |
| Inflammation | interacts_with | disease | 0.65 |
| Parkinson | interacts_with | disease | 0.65 |
| Autism | interacts_with | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Anxiety | interacts_with | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Depression | therapeutic_target | disease | 0.65 |
| Alzheimer | expressed_in | disease | 0.65 |
| Depression | causes | disease | 0.65 |
| CTSD | therapeutic_target | gene | 0.60 |
| NME1 | therapeutic_target | gene | 0.60 |
| CACNA1E | therapeutic_target | gene | 0.60 |
| CACNA2D3 | therapeutic_target | gene | 0.60 |
| PRKAB1 | therapeutic_target | gene | 0.60 |
| EPAS1 | therapeutic_target | gene | 0.60 |
| CEBPA | therapeutic_target | gene | 0.60 |
| PPARG | activates | gene | 0.60 |
| APOE | causes | gene | 0.60 |
| IL1B | regulates | gene | 0.60 |
| IL6 | regulates | gene | 0.60 |
| TP53 | regulates | gene | 0.60 |
| VEGFA | regulates | gene | 0.60 |
| SOD1 | regulates | gene | 0.60 |
| ACTB | regulates | gene | 0.60 |
| NRF2 | regulates | gene | 0.60 |
| APP | regulates | gene | 0.60 |
| APOE | regulates | gene | 0.60 |
| CASP3 | regulates | gene | 0.60 |
| SNCA | regulates | gene | 0.60 |
| NFE2L2 | regulates | gene | 0.60 |
| AKT1 | therapeutic_target | gene | 0.60 |
| PPAR | interacts_with | gene | 0.60 |
| APP | causes | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| cannabinoids | binds | compound | 0.95 |
| EPAS1 | therapeutic_target | gene | 0.60 |
| CACNG6 | therapeutic_target | gene | 0.60 |
| BIN1 | therapeutic_target | gene | 0.60 |
| CHRNA2 | therapeutic_target | gene | 0.60 |
| CEBPA | therapeutic_target | gene | 0.60 |
| NME1 | therapeutic_target | gene | 0.60 |
| PRKAB1 | therapeutic_target | gene | 0.60 |
| CACNA1E | therapeutic_target | gene | 0.60 |
| IL1B | causes | gene | 0.60 |
| SOD1 | regulates | gene | 0.60 |
| IL6 | causes | gene | 0.60 |
| TP53 | causes | gene | 0.60 |
| ACTB | causes | gene | 0.60 |
| SNCA | regulates | gene | 0.60 |
| NRF2 | causes | gene | 0.60 |
| APP | causes | gene | 0.60 |
| CASP3 | causes | gene | 0.60 |
| NFE2L2 | regulates | gene | 0.60 |
| VEGFA | causes | gene | 0.60 |
| AKT | interacts_with | gene | 0.60 |
| PI3K | interacts_with | gene | 0.60 |
| PPAR | interacts_with | gene | 0.60 |
| SIRT1 | therapeutic_target | gene | 0.60 |
| CXCL8 | therapeutic_target | gene | 0.60 |
| VEGFA | therapeutic_target | gene | 0.60 |
| APP | therapeutic_target | gene | 0.60 |
| TNF | therapeutic_target | gene | 0.60 |
| IL6 | therapeutic_target | gene | 0.60 |
| HSP90 | therapeutic_target | gene | 0.60 |
| MAPK1 | therapeutic_target | gene | 0.60 |
| NEFL | regulates | gene | 0.60 |
| RGS4 | regulates | gene | 0.60 |
| TAU | expressed_in | gene | 0.60 |
| NEFM | regulates | gene | 0.60 |
| HSP90 | causes | gene | 0.60 |
| TNF | causes | gene | 0.60 |
| AKT1 | targets | gene | 0.60 |
| APP | targets | gene | 0.60 |
| APP | associated_with | gene | 0.60 |
| BDNF | activates | gene | 0.60 |
| BDNF | causes | gene | 0.60 |
| BDNF | expressed_in | gene | 0.60 |
| AR | interacts_with | gene | 0.60 |
| GENES | therapeutic_target | gene | 0.60 |
| INFLAMMATION | regulates | gene | 0.60 |
| NEURODEGENERATION | causes | gene | 0.60 |
| OXIDATIVE STRESS | causes | gene | 0.60 |
| BTG2 | regulates | gene | 0.60 |
| ALS | causes | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||