Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ALZHEIMERS_DISEASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | ALZHEIMERS_DISEASE |
| Summary | Page for Basal Forebrain Cholinergic Neurons in Alzheimer's Disease |
| Key Genes/Proteins | TAU, C3, BAG3, SNCA |
| Related Diseases | REACTIVE_GLIOSIS, PARKINSONS_DISEASE, MULTIPLE_SCLEROSIS |
| Related Pathways | SYNAPSE_PATHWAY, MTOR_SIGNALING, PROTEOME, GLYCOLYSIS, MITOPHAGY |
Knowledge base pages for this entity
graph TD
ALZHEIMERS_DISEASE["ALZHEIMERS_DISEASE"]
ALZHEIMERS_DISEASE ---|"associated"| PARKINSONS_DISEASE["PARKINSONS_DISEASE"]
ALZHEIMERS_DISEASE ---|"associated"| MULTIPLE_SCLEROSIS["MULTIPLE_SCLEROSIS"]
C3["C3"] -->|"contributes to"| ALZHEIMERS_DISEASE
MEMANTINE["MEMANTINE"] -->|"treats"| ALZHEIMERS_DISEASE
TAU["TAU"] ---|"associated"| ALZHEIMERS_DISEASE
p_tau181["p_tau181"] ---|"associated"| ALZHEIMERS_DISEASE
amyloid_beta["amyloid_beta"] ---|"associated"| ALZHEIMERS_DISEASE
ASTROCYTES["ASTROCYTES"] ---|"associated"| ALZHEIMERS_DISEASE
SYNAPSE_PATHWAY["SYNAPSE_PATHWAY"] ---|"associated"| ALZHEIMERS_DISEASE| Target | Relation | Type | Str |
|---|---|---|---|
| PARKINSONS_DISEASE | associated_with | disease | 0.56 |
| MULTIPLE_SCLEROSIS | associated_with | disease | 0.56 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TAU | associated_with | protein | 0.87 |
| ASTROCYTES | associated_with | cell_type | 0.64 |
| SYNAPSE_PATHWAY | associated_with | pathway | 0.64 |
| MTOR_SIGNALING | associated_with | pathway | 0.64 |
| C3 | contributes_to | protein | 0.64 |
| MEMANTINE | treats | drug | 0.64 |
| REACTIVE_GLIOSIS | associated_with | phenotype | 0.64 |
| PROTEOME | associated_with | pathway | 0.56 |
| GLYCOLYSIS | associated_with | pathway | 0.56 |
| BAG3 | associated_with | protein | 0.56 |
| SNCA | associated_with | gene | 0.56 |
| MITOPHAGY | associated_with | pathway | 0.56 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 1 hypotheses Top: 0.462
neurodegeneration | 2026-04-03 | 17 hypotheses Top: 0.662
neurodegeneration | 2026-04-03 | 1 hypotheses Top: 0.502
neurodegeneration | 2026-04-02 | 0 hypotheses
neurodegeneration | 2026-04-02 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||