protein 3,068 words KG: NEPRILYSIN 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

Neprilysin (NEP / CD10 / MME)

🔬 Protein Info
Gene SymbolNEPRILYSIN
Chromosome3q25.2.
Protein TypeProtease
Functionis an important component in the neurobiology of neurodegenerative [diseases.
Primary ExpressionMembrane-bound, presynaptic
Subcellular LocalizationMembrane-bound, presynaptic
Amino Acids750 aa
PathwaysAmyloid, Apoptosis, Blood-Brain Barrier, Epigenetic, Neuroinflammatory
GeneCardsNEPRILYSIN
Human Protein AtlasNEPRILYSIN
Abeta404.3 kDa
Abeta424.5 kDa
Met-enkephalin0.6 kDa
Leu-enkephalin0.6 kDa
Substance PNeuropeptide, pain transmission
Associated DiseasesAlzheimer, Alzheimer'S Disease, disease
InteractionsAPP, STAT3, HDAC6, SIRT1, TRKB, FNDC5
KG Connections118 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (10)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Blood-Brain Barrier SPM Shuttle System
Score: 0.55
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48

Related Analyses (5)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (1)

Experiment Validation: In vitro ThT Assay
validation · proposed · Score: 0.46

See Also (5)

Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
AQP4 (Aquaporin-4 Gene)
gene · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates

Knowledge Graph (12 edges)

NEPRILYSIN activates APP
NEPRILYSIN inhibits STAT3
NEPRILYSIN inhibits HDAC6
NEPRILYSIN activates SIRT1
NEPRILYSIN activates TRKB
NEPRILYSIN inhibits FNDC5
NEPRILYSIN activates AHR
NEPRILYSIN activates TAU
NEPRILYSIN activates IDE
NEPRILYSIN activates GRIN2A