| Gene Symbol | NLGN1 |
| Full Name | Neuroligin-1 |
| Protein Family | receptor |
| Target Class | Receptor |
| Mechanism of Action | Drugs targeting NLGN1 would modulate synaptic adhesion by either enhancing or blocking the neuroligin-neurexin interaction at the postsynaptic membrane, thereby regulating synapse formation, stabilization, and synaptic transmission. Indirect modulators may enhance GABAergic signaling or vasopressin-mediated pathways that influence neuroligin-dependent synaptic maturation and plasticity. |
| Primary Expression | Cortex, Hippocampus, Prefrontal Cortex, Dentate Gyrus |
| Subcellular Localization | ** Postsynaptic membrane, dendritic spines |
| Druggability | Medium (0.45) |
| Clinical Stage | Phase II |
| Pathways | memory consolidation, excitatory synaptic transmission, synaptic plasticity, Synaptic Plasticity, Mtor |
| GeneCards | NLGN1 |
| Human Protein Atlas | NLGN1 |
| Extracellular Domain | Acetylcholinesterase-like catalytic domain |
| Transmembrane Region | Single-pass membrane anchor |
| Associated Diseases | ALZHEIMER, Alzheimer's disease, autism spectrum disorder, DEMENTIA, neurodegeneration |
| Known Drugs/Compounds | Balovaptan, Arbaclofen, NLGN1-targeting nanobodies, Alpha-neurexin modulators |
| Interactions | Actin, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, Amyloid-Beta, AMYLOID-BETA |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Trans-Synaptic Adhesion Molecule Modulation Trans-Synaptic Adhesion Molecule Modulation |
| KG Connections | 212 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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