protein 1,208 words KG: NLRP7PROTEIN 2026-03-28
kind:proteinsection:proteinsstate:published
Contents

NLRP7 Protein — NLR Family Pyrin Domain Containing 7

🔬 Protein Info
Gene SymbolNLRP7
Full NameNLR Family Pyrin Domain Containing 7
AliasesNOD27, CLR19.9
Chromosome19q13.42
Protein FamilyNLR family, NOD-like receptor family
Protein TypeReceptor
Functionis a member of the NOD-like receptor (NLR) family of proteins that plays complex roles in innate immunity, inflammation, and cellular homeostasis.
Subcellular LocalizationCytoplasm, Cytosol
Molecular Weight~106 kDa (871 amino acids)
Amino Acids956 aa
Exons10
PathwaysInflammasome, Innate Immunity, pyroptosis
UniProt IDQ8WX94
NCBI Gene ID199713
Ensembl IDENSG00000124313
GeneCardsNLRP7
Human Protein AtlasNLRP7
Associated DiseasesAutoimmune
InteractionsNLRP12, CARD8, NLRP1, GAIN, NLRP3, NLRP2
KG Connections47 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (12)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (9)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 3 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 3 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 3 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 3 hypotheses