gene

AIM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AIM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

403Connections

4Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

AIM2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, expressed in. Associated with Aging, Als, Atherosclerosis. Connected to 189 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	AIM2
Protein Family	AIM2-like receptor (ALR)
Function	AIM2 functions as a cytosolic DNA sensor forming the AIM2 inflammasome.
Subcellular Localization	Cytoplasm
Molecular Weight	39 kDa
Amino Acids	200 aa
Pathways	Apoptosis, Autophagy, Cholesterol, Ferroptosis, Immune Response
UniProt ID	Q9WZE6
GeneCards	AIM2
Human Protein Atlas	AIM2
Associated Diseases	Als, Atherosclerosis, Cancer, Dementia, Infection
Interactions	ACTB, Actin, ALZHEIMER, AMPK, AND, APOPTOSIS
KG Connections	403 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: AIM2 — AlphaFold Q9WZE6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

AIM2 Gene

gene · 1784 words

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Validated Hypothesis: Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 Proteinopathy Neuroinflammation in ALS/FTD

hypothesis · 5607 words

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Validated Hypothesis: Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Release Mechanism for AIM2 Inflammasome Activation in Neurodegeneration

hypothesis · 5540 words

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Validated Hypothesis: Mitochondrial DAMPs-Driven AIM2 Inflammasome Activation in Neurodegeneration

hypothesis · 5462 words

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Validated Hypothesis: Mitochondrial DNA-Driven AIM2 Inflammasome Activation in Neurodegeneration

hypothesis · 4756 words

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AIM2 Protein — Absent in Melanoma 2

protein · 1345 words

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Pathway Diagram

graph TD
    AIM2["AIM2"] -->|"associated"| Ms["Ms"]
    AIM2["AIM2"] -->|"associated"| Tumor["Tumor"]
    AIM2["AIM2"] -->|"regulates"| Als["Als"]
    AIM2["AIM2"] -->|"regulates"| Ms_1["Ms"]
    AIM2["AIM2"] -->|"regulates"| Inflammation["Inflammation"]
    AIM2["AIM2"] -->|"associated"| Dementia["Dementia"]
    IL1B["IL1B"] -->|"associated"| AIM2["AIM2"]
    CASP1["CASP1"] -->|"associated"| AIM2["AIM2"]
    ATG5["ATG5"] -->|"associated"| AIM2["AIM2"]
    NLRC4["NLRC4"] -->|"associated"| AIM2["AIM2"]
    style AIM2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (288)

Target	Relation	Type	Str
Inflammasome	activates	pathway	1.00
Inflammation	activates	disease	1.00
PANoptosome	component_of	structure	0.95
INFLAMMATION	activates	gene	0.90
pyroptosis	participates_in	pathway	0.80
Bacterial Infection	activates	disease	0.75
Infection	activates	disease	0.75
Neuroinflammation	promotes	process	0.75
Tumor	associated_with	disease	0.75
Melanoma	activates	disease	0.75
Inflammation	associated_with	disease	0.75
CASP1	associated_with	gene	0.70
Autophagy	associated_with	pathway	0.70
IL1B	associated_with	gene	0.70
TNF	associated_with	gene	0.70
PYCARD	associated_with	gene	0.70
NLRP3	associated_with	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
NLRC4	associated_with	gene	0.70
LAMP1	associated_with	gene	0.70
MITOCHONDRIAL DNA	activates	gene	0.70
Ferroptosis	associated_with	pathway	0.70
Oxidative Stress	associated_with	pathway	0.70
DNA	activates	gene	0.70
Autophagy	inhibits	pathway	0.70
pyroptosis	activates	process	0.70
NF-kB signaling	participates_in	pathway	0.70
Pyroptosis	associated_with	pathway	0.70
Atherosclerosis	associated_with	disease	0.65
Lymphoma	activates	disease	0.65
Infection	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
ALS	inhibits	disease	0.65
Ms	activates	disease	0.65
Als	regulates	disease	0.65
Sepsis	associated_with	disease	0.65
Ms	regulates	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
ALS	activates	disease	0.65
Als	associated_with	disease	0.65
Melanoma	associated_with	disease	0.65
Als	inhibits	disease	0.65
Aging	expressed_in	disease	0.65
Ms	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Senescence	contributes_to	disease	0.65

Incoming (115)

Source	Relation	Type	Str
h-var-6957745fea	targets_gene	hypothesis	0.90
h-var-d04a952932	targets_gene	hypothesis	0.90
h-var-af9eb8e59b	targets_gene	hypothesis	0.90
h-var-a0933e666d	targets_gene	hypothesis	0.90
ZBP1	interacts_with	protein	0.85
PYROPTOSIS	associated_with	gene	0.70
ASC	associated_with	gene	0.70
FERROPTOSIS	associated_with	gene	0.70
PYCARD	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
NLRP12	interacts_with	gene	0.60
HTRA2	associated_with	gene	0.60
MLKL	regulates	gene	0.60
RIPK1	activates	gene	0.60
TBK1	activates	gene	0.60
IRF3	activates	gene	0.60
ZBP1	regulates	gene	0.60
RIPK3	activates	gene	0.60
GSDMD	regulates	gene	0.60
CANCER	associated_with	gene	0.60
APOPTOSIS	regulates	gene	0.60
NFKB	associated_with	gene	0.60
PYROPTOSIS	causes	gene	0.60
INFLAMMATION	inhibits	gene	0.60
MARCH7	associated_with	gene	0.60
NF-ΚB	associated_with	gene	0.60
HDAC6	regulates	gene	0.60
IFI16	associated_with	gene	0.60
CARD8	associated_with	gene	0.60
NLRP1	associated_with	gene	0.60
PYCARD	expressed_in	gene	0.60
NAIP	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
NLRP1	expressed_in	gene	0.60
NLRP2	expressed_in	gene	0.60
ASC	expressed_in	gene	0.60
CD4	associated_with	gene	0.60
DNM1L	associated_with	gene	0.60
TFRC	associated_with	gene	0.60
CASP3	associated_with	gene	0.60
SREBP2	activates	gene	0.60
GASDERMIN	regulates	gene	0.60
DNA	activates	gene	0.60
ALZHEIMER	inhibits	gene	0.60
IL-1	inhibits	gene	0.60
IL-18	activates	gene	0.60
IL-1	activates	gene	0.60
SIRT2	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
ASC	inhibits	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Microglial AIM2 Inflammasome as the Primary Driver of TDP-43	0.824	neurodegeneration	What are the mechanisms by which gut mic
Mitochondrial DAMPs-Driven AIM2 Inflammasome Activation in N	0.805	neurodegeneration	What are the mechanisms by which gut mic
Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re	0.804	neurodegeneration	What are the mechanisms by which gut mic
Mitochondrial DNA-Driven AIM2 Inflammasome Activation in Neu	0.803	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861]	["Han X", "Sun S", "Sun Y", "Song Q", "Z	Autophagy	2020	1
Inhibition of autophagy in microglia and macrophages exacerbates innate immune r [PMID:36652438]	Hegdekar N, Sarkar C, Bustos S, Ritzel R	Autophagy	2023	0
Inflammasome assembly in neurodegenerative diseases. [PMID:37633753]	Singh J, Habean ML, Panicker N	Trends in neurosciences	2023	0
NLRP3/caspase-1/GSDMD-mediated pyroptosis exerts a crucial role in astrocyte pat [PMID:34877938]	Li S, Sun Y, Song M, Song Y, Fang Y, Zha	JCI insight	2021	0
Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodeg [PMID:30381407]	Gordon R, Albornoz EA, Christie DC, Lang	Science translational medicine	2018	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AIM2 in their description or question text

No additional research found