gene

AIM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AIM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

410Connections

4Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

AIM2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, expressed in. Associated with Aging, Als, Atherosclerosis. Connected to 189 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	AIM2
Aliases	AIM2, PYHIN4
Chromosome	6q25.1
Protein Family	HIN-200 (PYHIN) family
Function	AIM2 functions as a cytosolic DNA sensor forming the AIM2 inflammasome.
Subcellular Localization	Cytoplasm
Molecular Weight	39 kDa
Amino Acids	200 aa
Gene Type	Protein-coding
Pathways	Apoptosis, Autophagy, Cholesterol, Ferroptosis, Immune Response
UniProt ID	Q9UMG1
NCBI Gene ID	199
Ensembl ID	ENSG00000163568
GeneCards	AIM2
Human Protein Atlas	AIM2
Associated Diseases	ALS, Atherosclerosis, Cancer, Dementia, Infection
Interactions	ZBP1, MLKL, TLR9, RIPK1, PYCARD, UBIQUITIN
KG Connections	410 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: AIM2 — AlphaFold Q9WZE6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    AIM2["AIM2"] -->|"associated"| Ms["Ms"]
    AIM2["AIM2"] -->|"associated"| Tumor["Tumor"]
    AIM2["AIM2"] -->|"regulates"| Als["Als"]
    AIM2["AIM2"] -->|"regulates"| Ms_1["Ms"]
    AIM2["AIM2"] -->|"regulates"| Inflammation["Inflammation"]
    AIM2["AIM2"] -->|"associated"| Dementia["Dementia"]
    IL1B["IL1B"] -->|"associated"| AIM2["AIM2"]
    CASP1["CASP1"] -->|"associated"| AIM2["AIM2"]
    ATG5["ATG5"] -->|"associated"| AIM2["AIM2"]
    NLRC4["NLRC4"] -->|"associated"| AIM2["AIM2"]
    style AIM2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (294)

Target	Relation	Type	Str
Inflammasome	activates	pathway	1.00
Inflammation	activates	disease	1.00
PANoptosome	component_of	structure	0.95
INFLAMMATION	activates	gene	0.90
pyroptosis	participates_in	pathway	0.80
Tumor	associated_with	disease	0.75
Inflammation	associated_with	disease	0.75
Infection	activates	disease	0.75
Bacterial Infection	activates	disease	0.75
Melanoma	activates	disease	0.75
Neuroinflammation	promotes	process	0.75
TNF	associated_with	gene	0.70
PYCARD	associated_with	gene	0.70
LAMP1	associated_with	gene	0.70
CASP1	associated_with	gene	0.70
IL1B	associated_with	gene	0.70
NLRC4	associated_with	gene	0.70
NLRP3	associated_with	gene	0.70
Autophagy	associated_with	pathway	0.70
Pyroptosis	associated_with	pathway	0.70
Ferroptosis	associated_with	pathway	0.70
Oxidative Stress	associated_with	pathway	0.70
AUTOPHAGY	associated_with	gene	0.70
Autophagy	inhibits	pathway	0.70
MITOCHONDRIAL DNA	activates	gene	0.70
DNA	activates	gene	0.70
NF-kB signaling	participates_in	pathway	0.70
pyroptosis	activates	process	0.70
Ms	associated_with	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Dementia	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Autoimmune	regulates	disease	0.65
Melanoma	associated_with	disease	0.65
Als	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Infection	associated_with	disease	0.65
Sepsis	associated_with	disease	0.65
Als	activates	disease	0.65
Tumor	activates	disease	0.65

Incoming (116)

Source	Relation	Type	Str
h-var-6957745fea	targets_gene	hypothesis	0.90
h-var-d04a952932	targets_gene	hypothesis	0.90
h-var-af9eb8e59b	targets_gene	hypothesis	0.90
h-var-a0933e666d	targets_gene	hypothesis	0.90
ZBP1	interacts_with	protein	0.85
ASC	associated_with	gene	0.70
PYROPTOSIS	associated_with	gene	0.70
FERROPTOSIS	associated_with	gene	0.70
IL1B	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
NLRC4	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
TNF	associated_with	gene	0.60
MARCH7	associated_with	gene	0.60
PYCARD	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
HDAC6	regulates	gene	0.60
IFI16	associated_with	gene	0.60
CARD8	associated_with	gene	0.60
NLRP1	associated_with	gene	0.60
PYCARD	expressed_in	gene	0.60
NAIP	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
NLRP1	expressed_in	gene	0.60
NLRP2	expressed_in	gene	0.60
ASC	expressed_in	gene	0.60
CD4	associated_with	gene	0.60
DNM1L	associated_with	gene	0.60
TFRC	associated_with	gene	0.60
CASP3	associated_with	gene	0.60
GSDMD	activates	gene	0.60
NLRP12	interacts_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
SQSTM1	activates	gene	0.60
ASC	activates	gene	0.60
P62	activates	gene	0.60
SIRT2	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
ASC	inhibits	gene	0.60
HTRA2	associated_with	gene	0.60
MLKL	regulates	gene	0.60
RIPK1	activates	gene	0.60
TBK1	activates	gene	0.60
IRF3	activates	gene	0.60
ZBP1	regulates	gene	0.60
RIPK3	activates	gene	0.60
GSDMD	regulates	gene	0.60
SYK	activates	gene	0.60
JNK	activates	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Microglial AIM2 Inflammasome as the Primary Driver of TDP-43	0.601	neurodegeneration	What are the mechanisms by which gut mic
Mitochondrial DAMPs-Driven AIM2 Inflammasome Activation in N	0.582	neurodegeneration	What are the mechanisms by which gut mic
Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re	0.581	neurodegeneration	What are the mechanisms by which gut mic
Mitochondrial DNA-Driven AIM2 Inflammasome Activation in Neu	0.580	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

AIM2

Understanding Entity Pages

Summary

Wiki Pages (21)

AIM2 Gene

nlrc5-protein

NLRP3 Inflammasome Activation Pathway in Neurodegeneration

DNA Sensing Pathways in Neurodegeneration

cGAS-STING Pathway Dysregulation Hypothesis in Parkinson's Disease

ASC (PYCARD)

Pyroptosis

cGAS-STING Inhibitors for Parkinson's Disease

NLRP3 Inflammasome Pathway in Neurodegeneration

Pyroptosis in Neurodegeneration

FANCA Gene

cGAS-STING Cytosolic DNA Sensing Pathway in Neurodegeneration

Integrin Pathway Modulator Therapy for Neurodegeneration

Innate Immune Response in Neurodegeneration

CASP1 Gene

NAIP Gene

pyroptosis-signaling-pathway-neurodegeneration

csf1

aim2-inflammasome-modulator-therapy