CARD8

Understanding Entity Pages

This page aggregates everything SciDEX knows about CARD8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

CARD8 is a key regulator of the NLRP1/NLRP3 inflammasome involved in neuroinflammation and neurodegenerative diseases including Alzheimer's and Parkinson's.

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graph TD
    CARD8["<b>CARD8</b>"]
    Als{"Als"}
    CARD8 -->|"regulates"| Als
    Ms{"Ms"}
    CARD8 -->|"regulates"| Ms
    Inflammation{"Inflammation"}
    CARD8 -->|"regulates"| Inflammation
    NLRP1["NLRP1"]
    CARD8 -->|"associated with"| NLRP1
    INFLAMMATION["INFLAMMATION"]
    CARD8 -->|"regulates"| INFLAMMATION
    AIM2["AIM2"]
    CARD8 -->|"associated with"| AIM2
    NLRP3["NLRP3"]
    CARD8 -->|"associated with"| NLRP3
    Inflammasome(["Inflammasome"])
    CARD8 -->|"associated with"| Inflammasome
    Pyroptosis(["Pyroptosis"])
    CARD8 -->|"regulates"| Pyroptosis
    neurodegeneration["neurodegeneration"]
    CARD8 -->|"implicated in"| neurodegeneration
    PYROPTOSIS["PYROPTOSIS"]
    PYROPTOSIS -->|"regulates"| CARD8
    HDAC6["HDAC6"]
    HDAC6 -->|"regulates"| CARD8
    IFI16["IFI16"]
    IFI16 -->|"associated with"| CARD8
    style CARD8 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0